Chromosomal abnormality of chromosome 12 in pediatric lymphoma: Prognostic impact and tumor biology

小儿淋巴瘤 12 号染色体异常：预后影响和肿瘤生物学

基本信息

批准号：
13670194
负责人：
NAKAGAWA Atsuko
金额：
$ 2.18万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670194/
关键词：
MALIGNANT LYMPHOMA CHILDREN CHROMOSOMAL TRANSLOCATION PROGNOSIS

项目摘要

We reviewed 208 clinically suspected malignant lymphoma cases of under sixteen years old. All those clinically suspected cases were histologically evaluated and placed into 2 major groups: i.e., non-Hodgkin lymphoma (NHL, 134 cases) and other diagnosis (63 cases). Other diagnosis group included 12 Hodgkin lymphoma, 12 leukemias, 26 reactive lymphoid hyperplasia, 8 necrotizing histocytic lymphadenitis, and 5 others..134 NHL cases were classified according to WHO classification; 15 precursor B lymphoblastic lymphoma, 24 diffuse large B-cell lymphoma, 26 Burkitt lymphoma, 30 precursor T lymphoblastic lymphoma, 33 anaplastic large cell lymphoma, 2 peripheral T-cell lymphoma, and 4 other NHLs.In 5 cases of precursor B lymphoblastic lymphoma and 6 cases precursor T lymphoblastic lymphoma, three chromosomal translocations in pediatric acute lymphoblastic lymphoma, i.e., t(12;21)(p13;q22), t(4;11)(q21;q23), T(9;22)(q34;q11) were examined by FISH and by RT-PCR method. None of those chromosomal translocation or fusion transcripts was detected.As for prognosis, two patients (one with diffuse large B-cell lymphoma and the other with anaplastic large cell lymphoma) died due to aggressive disease. Prognostic analysis will be continued to determine the prognostic impact of histology, phenotype, clinical stage, and primary sites.

我们回顾了 208 例 16 岁以下临床疑似恶性淋巴瘤病例。所有这些临床疑似病例均经过组织学评估并分为两大组：即非霍奇金淋巴瘤（NHL，134 例）和其他诊断（63 例）。其他诊断组包括霍奇金淋巴瘤12例、白血病12例、反应性淋巴组织增生26例、坏死性组织细胞性淋巴结炎8例、其他5例。134例NHL病例按WHO分类；前体 B 淋巴母细胞淋巴瘤 15 例、弥漫性大 B 细胞淋巴瘤 24 例、伯基特淋巴瘤 26 例、前体 T 淋巴母细胞淋巴瘤 30 例、间变性大细胞淋巴瘤 33 例、外周 T 细胞淋巴瘤 2 例和其他 NHL。5 例前体 B 淋巴母细胞淋巴瘤6例前驱T淋巴细胞淋巴瘤，3例小儿急性淋巴细胞淋巴瘤染色体易位，即通过 FISH 和 RT-PCR 方法检查 t(12;21)(p13;q22)、t(4;11)(q21;q23)、T(9;22)(q34;q11)。没有检测到任何染色体易位或融合转录本。至于预后，两名患者（一名患有弥漫性大B细胞淋巴瘤，另一名患有间变性大细胞淋巴瘤）因侵袭性疾病死亡。将继续进行预后分析，以确定组织学、表型、临床分期和原发部位的预后影响。