The study on the role of fluoride in the formation of urinary calculi

氟化物在泌尿系结石形成中作用的研究

基本信息

批准号：
01570886
负责人：
KATO Takahiro
金额：
$ 1.41万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570886/
关键词：
Fluorosis Urolithiasis Thailand 弗素食事調査尿路結石弗素化合物

项目摘要

There are many urinary stone patients in the northern part of Thailand and we have seen these patients having bone fluorosis on X-ray.This time we were able to determine fluorine concentration of the drinking water and the urine of 61 urolithiasis patients in the northern part of Thailand under cooperation with Prof. V. Choomsai and prof. S. Wudhikarn. Mean age of 61 patients was 52.2 year-old. Thirty-nine patients were male and 22 patients were female. Ten patients (16.4%) in these patients had bone fluorosis on X-ray. Eight patients were male and 2 patients were female. The fluorine concentration of drinking water in 61 patients was 0.36 mg per liter. The fluorine concentration of urine in these patients was 1.02 mg per liter. The fluorine concentration of drinking water in 10 patients with bone changes was 0.81 mg per liter. The fluorine concentration of urine in these patients was 1.84 mg per liter. There was no significance between the patients with bone changes and without bone changes.We analyzed 12 urinary stones in 61 patients by using infrared analyzer. Calcium oxalate stones were 2, magnesium ammonium phosphate stones were 3, calcium oxalate and calcium phosphate stones were 5, and calcium oxalate and other's stones were 2. We analyzed 2 stones of Thai patients and 2 stones of Japanese patients by Electron Probe Micro Analyzer, X-ray Analyzer and Polarized Microscope.The urinary stone formation in northern Thailand seemed to be related to their foods and the state of sanitation and bone fluorosis to be the effect of the fluorine intake from foods and drinking water.We appreciate the helpful kindness of Prof. Vorvat Choomsai and Prof. Supot Wudhikarn, Division of Urology, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

泰国北部有很多泌尿系结石患者，我们在X光片上看到这些患者有氟骨症。这次我们测定了泰国北部61名尿石症患者的饮用水和尿液中的氟浓度泰国与 V. Choomsai 教授和教授合作S.Wudhikarn。 61 名患者的平均年龄为 52.2 岁。 39 名患者为男性，22 名患者为女性。这些患者中有 10 名（16.4%）X 线检查显示有氟骨症。 8 名患者为男性，2 名患者为女性。 61名患者饮用水氟浓度为0.36毫克/升。这些患者尿液中的氟浓度为每升1.02毫克。 10名骨变患者饮用水氟浓度为0.81毫克/升。这些患者尿液中的氟浓度为每升1.84毫克。有骨改变的患者与无骨改变的患者之间无显着性差异。我们采用红外分析仪对61例患者的12例尿路结石进行了分析。草酸钙结石 2 颗，磷酸镁铵结石 3 颗，草酸钙和磷酸钙结石 5 颗，草酸钙及其他结石 2 颗。我们通过电子探针显微分析仪分析了泰国患者的 2 颗结石和日本患者的 2 颗结石， X射线分析仪和偏光显微镜。泰国北部尿路结石的形成似乎与他们的食物和卫生状况有关，氟骨症也与这些因素有关。我们感谢泰国清迈大学医学院外科泌尿科 Vorvat Choomsai 教授和 Supot Wudhikarn 教授的热心帮助。