High performance modification of chemically synthesized biodegradable polyesters

化学合成可生物降解聚酯的高性能改性

基本信息

批准号：
13650945
负责人：
MITOMO Hiroshi
金额：
$ 2.3万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Poly(L-lactic acid) is biodegradable polymer made from sustainable resources such as corn starch. But it begins to be softening above the gloss transition temperatue (50℃). Therefore, PLLA was mixed with triallyl isocyanurate (TAIC). After mixed with TAIC, PLLA was irradiated at various irradiation doses. Gel fraction and degree of swelling were measured and evaluated crosslinking formation. At 3% concentration of TAIC, 50 kGy of irradiation dose were the best condition for modification of PLLA. For this sample, gel fraction and degree of swelling were 85% and 6%, respctively. Thermo- mechanical analysis (TMA) of untreated PLLA showed softening above glass transition temperature(Tg) and significant elongation at around 90℃, while crosslinked sample treated under above conditions showed slight softening above Tg and melting point Tm, however it retains original shape even at above Tm. Thermal stability of PLLA was also obtained by annealing at around 90℃, however, the crosslinked sample … More showed not only the heat stability but also chemical proofing with good solvent for PLLA, such as chloroform. Moreover, the crosslinked PLLA showed properties of shape memory, even after once melted. Melt-quenced PLLA has very low crystallinity, which causes poor heat stability, so we tried annealing PLLA sample mixed with TAIC followed by irradiation. This method showed TMA behavior of partially crosslinked PLLA, i.e., partially softening at Tm but retained its shape above Tm. Biodegradability of the crosslinked PLLA was retarded slightly by introduction of crosslinking, however, usually it proceeds biodegradation after hydrolysis, there are no problem after the treatment in practice.Other chemically synthesized biodegradable polymers (e.g., bionolle)were treated with blending with inorganic particles or TAIC or TMAIC. Thermal stable and shape memory biodegradable polymers were obtained by these methods. These chemically synthesized biodegradable polymers were biodegraded with bacteria. 33 strain of bacteria were isolated, which were investigated by physiologicolly and morphologically, ond they are found to be gram negative and gram positive bacteria and fungi. Less

聚（L-乳酸）是由可持续资源（例如玉米淀粉）制成的可生物降解聚合物。但是它开始在光泽过渡温度（50℃）上方变软。因此，将PLLA与三脂异氰尿素（TAIC）混合。与TAIC混合后，在各种辐照剂量下辐照PLLA。测量并评估了交联成的凝胶分数和肿胀程度。在3％浓度的TAIC时，50 kGy的辐射剂量是PLLA修饰的最佳条件。对于此样品，凝胶分数和肿胀程度为85％和6％，分发。未处理的PLLA的热机械分析（TMA）显示出在玻璃过渡温度（TG）上方的软化，在90°左右的速度伸长率显着伸长，而在上述条件下处理的交联样品在TG和熔点TM上方略有软化，但是即使在TM上方，它也保持原始形状。还可以通过在90℃左右退火获得PLLA的热稳定性，但是，交联样品不仅显示了热稳定性，而且还显示了具有良好PLLA（例如氯仿）的溶解度的化学验证。此外，即使在融化后，交联的PLLA也显示出形状记忆的特性。融化的PLLA具有非常低的结晶度，这会导致热稳定性不佳，因此我们尝试将混合与TAIC混合的PLLA样品随后进行辐射。该方法显示了部分交联的PLLA的TMA行为，即在TM处部分软化，但在TM上保持其形状。但是，通过引入交联的交联PLLA的生物降解性会稍微阻碍，但是，通常在水解后进行生物降解，在实践中治疗后，没有问题。其他化学合成的可生物降解聚合物（例如Bionelle）与内无机颗粒或taiC或taiC或TaiC或TaiC或Tamaic或Tamaic或Tamaic或Tamaic或Tamaic或Tamaic均可进行处理。通过这些方法获得了热稳定和形状的可生物降解聚合物。这些化学合成的可生物降解聚合物可与细菌生物降解。分离了33种细菌菌株，通过生理和形态学对此进行了研究，发现它们是革兰氏阴性和革兰氏阳性细菌和真菌。较少的