General study of development of periodontal disease examination

牙周病检查发展概况研究

• 批准号: 13357018
• 负责人: KAWAGUCHI Hiroyuki
• 金额: $ 31.45万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13357018/
• 关键词: Periodontal Disease; Diagnosis; Screening; Preiodontal Pathogen; PCR method; cytokine

We developed a new method to detect periodontal pathogens. PCR method is very useful for making periodontal treatment plan and decision of prognosis. DNA microarray is also useful to know state of periodontal disease. On the other hand, we developed useful diagnosis method for disease sensitivity. Fc γ receptor gene regulates the production of inflammatory cytokines. Fc γ receptor polymorphisms affect the host response to bacterial attack. Profile analysis of inflammatory related factors from tissues, saliva, or gingival crevicular fluids (GCF) is available for the development of new therapy. Glycosaminoglycan level in GCF correlated with alveolar bone resorption. The measurement of calprotectin from GCF is associated with the activity of periodonttitis. Moreover we identified that volatile sulfer compound of expiration is closely correlated with periodontal disease. We developed a new method to detect traumatic occlusion using tooth fixation. To examine the effect of periodontitis for the body, we identified that high sensitivity CRP is very useful.

我们开发了一种检测牙周病原体的新方法，对于制定牙周治疗计划和判断预后非常有用，另一方面，我们开发了有用的疾病敏感性诊断方法。 Fc γ 受体基因调节炎症细胞因子的产生，影响宿主对组织、唾液或龈沟液中炎症相关因子的反应。 (GCF)可用于开发与牙槽骨吸收相关的糖胺聚糖水平。此外，我们还发现呼气的挥发性硫化合物与牙周炎的活动密切相关。我们开发了一种使用牙齿固定来检测创伤性咬合的新方法，为了检查牙周炎对身体的影响，我们发现高敏感性 CRP 非常有用。有用。

项目成果

Sakamoto M, Umeda M, et al.: "Reclassification of Bacteroides forsythus as Tanerrela forsythensis corrig"gen.Nov.comb.Nov.Int J.Syst Evol Microbiol. 52. 841-849 (2002)

Sakamoto M、Umeda M 等人：“福赛拟杆菌重新分类为 Tanerrela forsythensis corrig”gen.Nov.comb.Nov.Int J.Syst Evol Microbiol。

Nishimura F., and et al.: "Periodontal disease and diabetes mellitus : the role of tumor nectosis factor-α in a 2-way relationship"J. Periodontal. 74. 97-102 (2003)

Nishimura F. 等人：“牙周疾病和糖尿病：肿瘤坏死因子-α 在双向关系中的作用”J.牙周病杂志 74. 97-102 (2003)

Setoguchi T., Izumi Y., and et al.: "The effects of methyl-mercoptan on epithelial cell growth and proliferation"International Dental Journal. 52. 241-246 (2002)

Setoguchi T.、Izumi Y. 等人：“甲硫醇对上皮细胞生长和增殖的影响”国际牙科杂志。

Nakamura T., Junichi Kido, and et al.: "The association of cal protection level in gingival crevicular fluid with gingival index and the activities of collagenase and aspartate"J. Periodontal. 71. 361-367 (2000)

Nakamura T.，Junichi Kido，等人：“龈沟液中钙保护水平与牙龈指数以及胶原酶和天冬氨酸活性的关系”J。

Oshima M, et al.: "Hepotocyte grouth factor in saliva : a possiblemarker for periodontal disease status"J Oral Sci. 40. 35-39 (2002)

Oshima M 等人：“唾液中的肝细胞生长因子：牙周病状态的可能标志物”J Oral Sci。