DEVELOPMENT OF A SMARTPHONE-BASED INFRARED-FLUORESCENCEIMAGING INTRAORAL DEVICE (SMART-IR-ID) FOR DENTIST-GUIDED REALTIME SELF-MONITORING OF PERIODONTAL DISEASE

开发基于智能手机的红外荧光成像口内设备 (SMART-IR-ID)，用于牙医引导的牙周疾病实时自我监测

• 批准号: 10293078
• 负责人: KAIMING YE
• 金额: $ 22.26万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-28 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293078
• 关键词: 3-Dimensional; Address; Adult; Affect; Algorithmic Analysis; Algorithmic Software; American; Angiography; Area; Biological Models; Cardiovascular Diseases; Caring; Cellular Phone; Clinic; Clinical; Dental; Dental Hygiene; Dental Hygienists; Dental Offices; Dentists; Dentures; Development; Devices; Diabetes Mellitus; Diagnosis; Diagnostic; Diagnostic Equipment; Diagnostic Imaging; Disease; Disease Management; Disease Progression; Dose; Early Diagnosis; Early treatment; Economic Burden; FDA approved; Family suidae; Fluorescent Dyes; Future; Gingiva; Goals; Health; Height; Hemorrhage; High Prevalence; Image; Image-Guided Surgery; Imaging Device; In Vitro; Indocyanine Green; Inflammation; Inflammatory; Ionizing radiation; Jaw; Laboratories; Lesion; Link; Measurement; Measures; Mediating; Methods; Modality; Modeling; Monitor; Operative Surgical Procedures; Oral; Oral health; Organ; Outcome; Perfusion; Periodontal Diseases; Periodontal Ligament; Periodontal Pocket; Periodontitis; Periodontium; Permeability; Population; Public Health; Redness; Reporting; Research; Resources; Risk; Roentgen Rays; Saliva; Screening procedure; Self Care; Structure; Swelling; System; Technology; Testing; Therapeutic; Thick; Three-Dimensional Imaging; Time; Tissues; Tooth Loss; Tooth structure; Visual; Work; alveolar bone; base; bone; checkup examination; chronic inflammatory disease; clinical care; clinical research site; digital; disease diagnosis; dosage; fluorescence imaging; fluorophore; follow-up; imaging agent; imaging approach; imaging system; innovation; lymph node biopsy; mHealth; medically underserved; optical sensor; patient oriented; photothermal therapy; precision medicine; prevent; prototype; real time monitoring; routine screening; sensor; socioeconomics; soft tissue; three dimensional structure; three-dimensional modeling; virtual model

PROJECT SUMMARY: Periodontal disease (PD), a common infectious/inflammatory disease, is preventable for much of the population by early detection and treatment; however, the high prevalence of PD (47% of Americans adults having periodontitis) makes it a public health concern, having a socio-economic burden of up to $442 billion each year. PD is typically diagnosed by the dental hygienist, dentist, or periodontist tracking alveolar bone height and gingival height through intraoral radiographs (X-rays) and periodontal probing. Dental X-rays are the most reliable intraoral imaging tool for identifying tooth/cavity conditions and bone lesions; however, dental X-rays cannot detect early periodontal lesions and visualize the topography of periodontal pocket (PP). Also, dental X-rays cannot be used as a routine screening tool to exam the progression of PD during the follow-up period because its ionizing radiation poses health risks and concerns. Periodontal probing is, therefore, the standard approach for complete PD diagnosis and follow-up checkups. The structural status of the periodontal soft tissues can be estimated by pocket depth measurement, gingival bleeding, and visual signs of gingival inflammation (redness and swelling). To the best of our knowledge, there is still no reliable technology that can provide 3D structure information of the PP and inflamed gingiva during PD progression. The objective of this proposal is to develop a smartphone-based infrared-fluorescence-imaging intraoral device (Smart-IR-ID) to measure the 3D structure of the PP and gingival inflammation for dentist-guided self-exam and tracking of PD. We propose to address this objective through 2 specific aims: 1) To investigate the infrared (IR) fluorescence imaging approach to develop IR intraoral devices that can precisely deliver and release the minimal required dosage of imaging agents into inflamed gingiva and PP; and 2) To develop the dual-module optical sensors and smartphone-based 3D modeling system for digital 3D IR-imaging and reporting the 3D measurements of PP and gingival inflammation. Our proposed project is innovative as a smartphone-based intraoral IR fluorescence imaging system in visualizing the 3D structure of PP and infected soft tissue of periodontium is a completely underexplored research area. The expected outcome of this work is to provide the pioneering prototype for our precision medicine-based intraoral imaging device integrated into a mHealth platform. Smart- IR-ID, in particular, opens the possibility of combining imaging and therapeutic capabilities at the next stage. Our project is significant because this research will develop a platform-specific model that can be linked to other intraoral diagnostic and therapeutic devices, transforming PD management from on-site clinical care in clinic facilities to dentist-guided self-care at the point-of-need.

项目摘要： 牙周疾病（PD）是一种常见的传染性/炎症性疾病，可以预防大部分 人口通过早期检测和治疗；但是，PD的高患病率（47％的美国人成年人 患有牙周炎）使其成为公共健康问题，具有高达4420亿美元的社会经济负担 每年。 PD通常由牙科卫生师，牙医或牙周病医生诊断 高度和牙龈高度通过口腔内X光片（X射线）和牙周探测。牙科X射线是 识别牙齿/空腔状况和骨骼病变的最可靠的口腔成像工具；但是，牙齿 X射线无法检测到牙周病变的早期牙周病变，并可视化牙周口袋（PP）的地形。还， 牙齿X射线不能用作常规筛选工具，以检查随访期间PD的进展 时期，因为其电离辐射会带来健康风险和关注点。因此，牙周探测是 完整PD诊断和随访检查的标准方法。牙周的结构状态 软组织可以通过口袋深度测量，牙龈出血和牙龈的视觉迹象来估计 炎症（发红和肿胀）。据我们所知，仍然没有可靠的技术可以 在PD进展过程中提供PP和发炎的3D结构信息。这个目的 提案是为基于智能手机的红外荧光成像内部设备（SMART-IR-ID）开发 测量PP和牙龈炎症的3D结构，用于牙医引导的自我检查和PD跟踪。 我们建议通过2个特定目的来解决这一目标：1）研究红外（IR）荧光 成像方法开发IR内部设备，可以精确传递和释放所需的最小值 成像剂剂量成牙龈和PP； 2）开发双模块光传感器 以及用于数字3D IR成像的基于智能手机的3D建模系统，并报告了3D测量 PP和牙龈发炎。我们提出的项目是一种基于智能手机的手机内红外线的创新性 荧光成像系统可视化PP的3D结构和牙周感染的软组织是一个 完全没有置换的研究领域。这项工作的预期结果是提供开创性 我们基于精确医学的口腔成像设备的原型集成到MHealth平台中。聪明的- 尤其是IR-ID，在下一阶段开辟了结合成像和治疗能力的可能性。 我们的项目很重要，因为这项研究将开发一个特定于平台的模型，可以与 其他口腔内诊断和治疗设备，将PD管理从现场临床护理转化为 牙医指导自我保健的诊所设施。