Study of erectile dysfunction with penile vascular changes in hypertension patients

高血压患者勃起功能障碍与阴茎血管变化的研究

• 批准号: 12671532
• 负责人: NAGAI Atsushi
• 金额: $ 1.47万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671532/
• 关键词: erectile dysfunction; cardiovascular disease; hypertension; perfusion pressure; 内陰部動脈

In hypertension patients, small arteries in a variety of vascular beds undergo structural changes that increase resistance. To assess whether there are differential structural changes in the penis that accompany hypertension, we began with determining structurally - based vascular resistance properties in penile and hindlimb vascular beds of adult spontaneously hypertensive rats (SHR) and Sprague - Dawley (SD)rats.In anesthetized SHR, the penile and hindlimb vasculature were isolated and perfused, maximum dilatation was induced, and a flow-pressure assessment and □1- adrenoceptor agonist concentration - response curves were generated. Both the baseline and maximum constrictor responses were similar in the two beds of each strain, and overall the maximum structurally-based vascular resistance in SHR was higher than in SD rats.Our data suggests that the penile vasculature is not protected from the structural changes that take place in the other vascular beds in hypertension. There does not appear to be an underlying functional control mechanism that protects the penile vasculature from structural changes that may have a negative impact on penile blood flow.

在高血压患者中，各种血管床中的小动脉会发生结构变化，从而增加阻力。为了评估阴茎是否存在伴随高血压的不同结构变化，我们首先确定阴茎和后肢血管床中基于结构的血管阻力特性。成年自发性高血压大鼠（SHR）和斯普拉格-道利（SD）大鼠。在麻醉的 SHR 中，分离并灌注阴茎和后肢脉管系统，最大扩张为诱导，并生成了流量-压力评估和α1-肾上腺素受体激动剂浓度-响应曲线，每个菌株的两个床中的基线和最大收缩器响应相似，并且总体上SHR中基于结构的最大血管阻力为。高于 SD 大鼠。我们的数据表明，阴茎脉管系统不受高血压其他血管床发生的结构变化的影响。似乎不存在保护阴茎脉管系统的潜在功能控制机制。阴茎脉管系统结构变化可能对阴茎血流产生负面影响。

项目成果

永井敦: "岡山大学医学部附属病院泌尿器科性機能外来におけるシルデナフィル処方の現状"日本性科学雑誌. 18巻1号. 9-13 (2000)

Atsushi Nagai：“冈山大学医院泌尿外科门诊的西地那非处方现状”《日本性学杂志》第 18 卷，第 1. 9-13 期（2000 年）。

新 良治: "膀胱全摘術後患者の性機能障害"西日本泌尿器科. 62巻5号. 290-296 (2000)

Ryoji Shin：“根治性膀胱切除术后患者的性功能障碍”，西日本泌尿外科杂志，第 62 卷，第 5 期，290-296（2000 年）。

Nagai A: "Clinical effects of Sildenafil on Erectile Dysfunction at the Outpatient Clinic of the Department of Urology, Okayama University Medical School."Japanese Journal of Sexology. 18-2. 9-13 (2000)

Nagai A：“冈山大学医学院泌尿外科门诊的西地那非对勃起功能障碍的临床效果。”《日本性学杂志》。

Iguchi H: "Treatment of erectile dysfunction with sildenafil citrate at the outpatient clinic of Okayama University Hospital."The Japanese Journal of Impotence Research. 16-1. 33-38 (2001)

Iguchi H：“冈山大学医院门诊用柠檬酸西地那非治疗勃起功能障碍。”日本阳痿研究杂志。

白井 將文: "勃起不全に対する経口治療薬シルデナフィルの無作為化二重盲検プラセボ対照比較試験"西日本泌尿器科. 62巻6号. 373-382 (2000)

Masafumi Shirai：“西地那非（一种治疗勃起功能障碍的口服药物）的随机、双盲、安慰剂对照比较研究”，Nishi-Nippon Urology，第 62 卷，第 6 期。373-382（2000 年）。