Analysis of the lmbic neural circuits concerned with orofacial movements

与口面部运动有关的腰部神经回路分析

基本信息

批准号：
11680740
负责人：
YASUI Yukihiko
金额：
$ 1.92万
依托单位：
Shimane Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680740/
关键词：
Limbic system Amygadaloid body Orofacial movement Motor trigeminal nucleus Facial nucleus Premotor neuron Reticular formation Emotion 小細胞性網様体

项目摘要

We have been studied on the control pathways from the central amygdaloid nucleus (ACe) to the motor trigeminal and facial nuclei. We examined the distribution of efferent fibers from the ACe and that of premotor neurons projecting directly to the motor trigeminal or facial nucleus, using a combined anterograde and retrograde tracing method with biotinylated dextranamine and cholera toxin B subunit.As a result, the good overlapping distribution of the ACe fibers and premotor neurons was found mainly in the parvicellular reticular formation of the pons and medulla oblongata, additionally in the nucleus of the solitary tract and the sensory trigemunal nuclei. Whithin the parvicellular reticular formation, the bouton-like varicosities of the ACe fibers were often observed to be closely apposed to the somata and dendrites of the premotor neurons. In the electron microscopic level, it was revealed that the ACe fibers made asymmetrical synapses predominantly with dendrites and partly with somata of the premotor neurons. Furthermore, synaptic dense bodies were often observed in the active zone of the axo-dendritic synapses.Thus, the present data suggest that the ACe may take part in the control of emotional orofacial movements through its descending projections to the motor trigeminal and facial nuclei via the parvicellular reticular neurons.

我们研究了从中央杏仁核（ACe）到运动三叉神经核和面部核的控制通路。我们使用生物素化右旋糖酐和霍乱毒素 B 亚基的顺行和逆行相结合的追踪方法，检查了 ACe 传出纤维的分布以及直接投射到运动三叉神经或面核的运动前神经元的分布。结果，良好的重叠分布ACe 纤维和运动前神经元的结构主要存在于脑桥和延髓的小细胞网状结构中，此外还存在于孤神经元的核中。束和感觉三叉神经核。在小细胞网状结构中，经常观察到 ACe 纤维的布顿样静脉曲张与前运动神经元的体细胞和树突紧密相连。在电子显微镜水平上，研究表明 ACe 纤维主要由树突和部分前运动神经元体构成不对称突触。此外，在轴突-树突突触的活动区经常观察到突触致密体。因此，目前的数据表明，ACe可能通过其向下投射到运动三叉神经和面部核团来参与情绪口面部运动的控制。小细胞网状神经元。