A new type of neutron capture therapy against malignant tumors using medical nuclear reactor

利用医用核反应堆治疗恶性肿瘤的新型中子捕获疗法

基本信息

批准号：
11794021
负责人：
MATSUMURA Akira
金额：
$ 7.49万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for University and Society Collaboration
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11794021/
关键词：
neutron capture therapy charged particle therapy alpha particle malignant glioma glioblastoma boron radiation therapy intraoperative radiation therapy 悪性神経膠腫熱外中性子 α線ガドリニウム悪性脳腫瘍原子炉

项目摘要

[Basic Physics Study] Before using epi-thermal neutron to the patients, basic studies for neutron beam characterization have been performed. We used water phantom, cultured cells for measurement. The RBE of the each beam component has been calculated, which can be applied to the clinical dose evaluation. Besides, the treamtne planning system (so called JCDS system) has been also developed for JRR-4 boron neutron capture therapy (BNCT) project.[Basic Oncology Study] To improve the boron delivery to the tumor cells, we have developed a new boronated porphyrin and have examined using in vitro cultured glioma cells and have shown that this compound effectively accumulate in the tumor cells and show cytotoxic effect after neutron irradiation. We have also analyzed the boron uptake in two boronated compounds currently used in clinical trial by means of the cell cycle dependency. Both compound showed different behavior and based on this result we may use two compounds simultanesouly for clinical trial since they cover different cell population in the cell cycle.[Clinical Study] Since October 1999, a new clinical phase I/II trial using mixed thermal-epithermal beam with open craniotomy has been conducted at the new JRR-4 reactor with full medical equipment installed. So far, there have been 9 patients treated and the phase I/II finished. The median survival of Glioblastoma cases is 15.4 months and 16months for anaplastic astrocytomas. This result is favorable for phase I/II study and merits for further new protocol using pure epithermal beam.

[基础物理学研究]在对患者使用表皮中性中子之前，已经进行了中子束表征的基础研究。我们使用水幻影，培养的细胞进行测量。已经计算了每个光束成分的RBE，可以应用于临床剂量评估。此外，还为JRR-4硼中子捕获疗法（BNCT）项目开发了Treamtne计划系统（所谓的JCDS系统）。[基本肿瘤学研究]为了改善向肿瘤细胞的硼硼递送，我们已经开发了一种新的硼酸卟啉并使用体外培养的神经胶质瘤细胞检查，并表明该化合物有效地在肿瘤细胞中积累，并在中子照射后显示出细胞毒性作用。我们还通过细胞周期依赖性分析了目前在临床试验中使用的两种硼化化合物中的硼摄取。两种化合物均表现出不同的行为，基于这一结果，我们可以使用两种化合物进行临床试验，因为它们在细胞周期中涵盖了不同的细胞群体。[临床研究]自1999年10月以来，这是一项新的临床I/II阶段试验。已安装了完整的医疗设备的新JRR-4反应堆进行了带有开颅切开术的表情梁。到目前为止，已经接受了9名患者，I/II期已经完成。胶质母细胞瘤病例的中位存活率为15.4个月，而对层状星形胶质细胞瘤的中位数为16个月。该结果有利于使用纯表表束的I/II期研究和更优点。