Research on role of chemokine in reproductive physiology

趋化因子在生殖生理中的作用研究

• 批准号: 11671603
• 负责人: KOIKE Koji
• 金额: $ 2.3万
• 依托单位: kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671603/
• 关键词: stress; Chemokine; CINC; Gro-α; Hypoglycemia; Human; Rat; Hypothalamus; ケモンカイン; 分娩; 運動

Recently, we have demonstrated that in rats an immobilization stress evokes the activation of chemokinergic neuronal pathway which results in the release of cytokine induced neutrophil chemoattractant (CINC) into the peripheral blood from the hypothalamo-neurohypophysial system. This observation prompted us to investigate the effect of insulin-induced hypoglycemia on CINC neuronal pathway in the hypothalamo-pituitary system. An insulin injection decreased the plasma glucose level, which followed a prompt rise in plasma ACTH level and an increase in serum CINC level. Before the insulin injection, the signal for CINCmRNA was undetectable in the paraventricular hypothalamic nucleus (PVN). The hypoglycemic challenge induced strong hybridization signals of CINC mRNA in the parvocellular and magnocellular subdivision of the PVN, suggesting the presence of a hypoglycemia-sensitive chemokinergic neuronal pathway in the hypothalamo-neurohypophysial system. To examine the possibility that similar responses occur in human, we investigated whether strenuous exercise evokes a rise in serum GRO-α. There was a significant rise in serum GRO-α level after strenuous exercise. These data suggest that GRO-α responds to exogenous stress as well as CINC does through chemokinergic neuronal pathway

最近，我们已经证明，在大鼠中，固定应力引起了趋化性神经元的激活，从而导致e诱导的中性粒细胞趋化剂（CINC）从假设的神经系统中的媒介系统中诱导的中性粒细胞趋化剂（CINC）。 - 在胰岛素注入cincmrna之前，诱发的糖类垂体垂体系统迅速上升。 pvn的巨大细胞细胞在下丘脑 - 神经植物学系统中检查了人类中的类似反应，我们研究了血清gro-α的血清gro-α水平的上升。这些数据表明，GRO-α对外源性应激以及CINC的反应响应于themokineragic神经元途径

项目成果

Z Wang et al: "Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway"Cancer Res. 60. 5376-5381 (2000)

Z Wang 等人：“黄体酮通过激活丝裂原激活蛋白激酶信号通路调节人端粒酶逆转录酶基因表达”Cancer Res。

Wang Z et al: "Progesterone regurates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway."Cancer Res. 60. 5376-5381 (2000)

Wang Z 等人：“黄体酮通过激活丝裂原激活蛋白激酶信号通路来调节人端粒酶逆转录酶基因表达。”Cancer Res。

Masuhara K et al: "Involvement of extracellular signal-regulated protein kinase in gliosis induced during recovery from inhibition."Biochem Biophys Res Commun. 267. 892-896 (2000)

Masuhara K 等人：“细胞外信号调节蛋白激酶参与抑制恢复过程中诱导的神经胶质增生。”Biochem Biophys Res Commun。

Osako Y et al: "Insulin-induced hypoglycemia activates a chemokinergic neuronal pathway in the hypothalamo-pituitary system."Neuropeptide. 33. 271-275 (1999)

Osako Y 等人：“胰岛素诱导的低血糖激活下丘脑-垂体系统中的趋化神经元通路。”神经肽。

Kimura A et al: "Mitogen-activated protein kinase cascade is involved in endothelin-1-induced rat puerperal uterine contraction."Endocrinology. 140. 722-731 (1999)

Kimura A 等人：“丝裂原激活蛋白激酶级联参与内皮素-1 诱导的大鼠产后子宫收缩。”内分泌学。