Mechanism of stress-induced derangement of gonadal function in the neuro-endocrine-immune networks

应激引起的神经内分泌免疫网络性腺功能紊乱的机制

• 批准号: 14571546
• 负责人: KOIKE Koji
• 金额: $ 2.24万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571546/
• 关键词: Reproductive physiology; Chemokine; Stress; Estrogen; Cytokine; Gonadal function

There is a growing body of evidence that the neuroendocrine and immune systems are engaged in a functionally relevant crosstalk with each other. These interactions are also directly linked to the stress system and derangement of this system will lead to the impairment of protective function in neural system against to the stress.In the monkey hippocampus, we found microglial cells expressed ELR+ CXC chemokines and their receptor CXCR2 after the start of ischemia and reperfusion and on day 4 after ischemia, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1 in the monkey hippocampus. Further, we found that Unkei-to has a functional antagonistic action on the response to CRF and may attenuate stress responses, we assess whether the herbal medicine Unkei-to has an impact on HRT-resistant menopausal depressive symptoms as an effective adjunctive therapy combined with HRT. We found treatment with Unkei-to was significantly effective in reduction of depression score and that Unkei-to is another option as an adjunctive herbal therapy in HRT-resistant menopausal depressive women.

神经内分泌和Imune系统从事磨难的越来越多的证据也与压力系统直接相关，该系统将导致保护性侵袭性系统损害压力。缺血后的第4天，ERβ的免疫反应性在猴子河马的辐射和分子层中增加了显着，发现Unkei-to对CRF的反应具有功能性拮抗作用 - 对HRT的绝经抑制症状有影响在耐HRT的绝经中抑郁症。

项目成果

小池浩司他: "生殖器の萎縮・セクシャリティ"臨床婦人科産科. 56. 1340-1344 (2002)

Koji Koike 等人：“生殖器萎缩和性行为”《临床妇产科》56. 1340-1344 (2002)。

Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms

• DOI: 10.1097/01.wnf.0000138634.34498.05
• 发表时间: 2004-07-01
• 期刊: CLINICAL NEUROPHARMACOLOGY
• 影响因子: 1
• 作者: Koike, K;Ohno, S;Inoue, M
• 通讯作者: Inoue, M

The factor relating ego in middle aged women going regularly to gynecology

中年女性定期就诊妇科的自我意识影响因素

• 发表时间: 2004
• 期刊: J Jpn Menopause Soc 12
• 作者: Sakai A

小池浩司他: "子宮筋腫の管理:子宮筋腫のホルモン療法"産婦人科治療. 86. 274-278 (2003)

Koji Koike 等人：“子宫肌瘤的治疗：子宫肌瘤的激素疗法”妇产科治疗。 86. 274-278 (2003)

Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion

• DOI: 10.1016/s0006-8993(03)02343-6
• 发表时间: 2003-04
• 期刊: Brain Research
• 影响因子: 2.9
• 作者: B. Popivanova;K. Koike;A. Tonchev;Y. Ishida;T. Kondo;S. Ogawa;N. Mukaida;M. Inoue;T. Yamashima