Gene Analysis of Cardiac ion channel genes on Sudden Infant Death Syndrome (SIDS) and Youth Sudden Death.

婴儿猝死综合症（SIDS）和青少年猝死的心脏离子通道基因的基因分析。

• 批准号: 11670427
• 负责人: SAITO Kazuyuki
• 金额: $ 2.24万
• 依托单位: SAITAMA MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670427/
• 关键词: SIDS; Cardiac ion channel genes; LQT-2; LQT-3; PCR-SSCP; Japanese; 法医病理; SSCP; シーケンス解析; LQT2; 同義置換

On the Sudden Infant Death Syndrome (SIDS) case, PCR-SSCP analysis of the heart ion channel gene region was carried out in fiscal 1999 and 2000. In fiscal 2001, the genetic analysis of the heart ion channel gene region was carried out on the eucrasia object group as well as the SIDS case. Then, SIDS case and analytical result of the normal contrast group were compared and were examined. 2 intergroup between SIDS and normal contrast group could not recognize the significance the result for DAN Polymorphism distribution in LQT-3 gene region and LQT-2. That is to say, the SIDS case could not recognize LQT-2 and relevance to the LQT-3 gene. And, all cases were diagnosed as SIDS on all SIDS cases of the genetic analysis, when death circumstantial investigation and pathomorphological case examination were carried out

在婴儿猝死综合症（SIDS）案例中，于1999财年和2000财年进行了心脏离子通道基因区域的PCR-SSCP分析。2001财年，对心脏离子通道基因区域进行了遗传分析。 eucrasia 对象组以及 SIDS 案例。然后，将SIDS病例与正常对照组的分析结果进行比较和检验。 2 SIDS和正常对照组之间的组间不能识别LQT-3基因区域和LQT-2基因区域的DAN多态性分布结果的显着性。也就是说，SIDS病例无法识别LQT-2以及与LQT-3基因的相关性。并且，在进行死亡情况调查和病理形态学检查时，对所有SIDS病例进行基因分析，所有病例均被诊断为SIDS

项目成果

齋藤一之, 高田綾: "突然死例にみる脳動脈瘤と動脈解離"医学のあゆみ:動脈瘤と動脈解離の最前線. 別冊. 111-115 (2001)

Kazuyuki Saito，Aya Takada：“猝死病例中的脑动脉瘤和动脉夹层”医学史：动脉瘤和动脉夹层的前沿特卷111-115。

T Murai, K Saito et al.: "Sudden death due to cardiovascular disorders : a review of the studies on the medico-legal cases in Tokyo"Keio J Med.. 50. 175-181 (2001)

T Murai, K Saito 等：“心血管疾病引起的猝死：东京法医案例研究回顾”Keio J Med.. 50. 175-181 (2001)

Aya Takada, et al: "Papillary fibroelastoma of the aortic valve : a sudden death case of coronary embolism with myocardial infarction"Forensic Science International. 113. 209-214 (2000)

Aya Takada 等人：“主动脉瓣乳头状弹力纤维瘤：冠状动脉栓塞伴心肌梗死的猝死病例”国际法医科学。