Magnetic resonance imaging of breast cancer : Correlation between contrast enhancement and tumor angiogenesis

乳腺癌的磁共振成像：对比增强与肿瘤血管生成之间的相关性

基本信息

批准号：
10671092
负责人：
OHUCHI Noriaki
金额：
$ 1.47万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671092/
关键词：
Breast cancer Breast conserving 3-D MR imaging Angiogenesis Histological grade 乳癌温存療法 3次元MRI画像

项目摘要

[Purpose] To evaluate the association between enhancement characteristics of breast cancers obtained by three-dimensional dynamic MRI and histopathologic findings, especially tumor angiogenesis.[Materials and Methods] Forty-four women with invasive breast cancer underwent preoperative MR imaging. Three-dimensional fast flow angle shot (3D-FLASH) images of the whole breast (section thickness, 2 mm ; gap, 0 mm ; number of sections, 50 ; acquisition time, 87 sec) were obtained at 90-second intervals for three times (the first images before injection of Gd-DTPA). Microvessel densities were evaluated in specimens immunohisto-chemically stained with anti-CD34 antibody. The person correlation tests were used to determine the strength of the relationships between enhancement parameters and microvessel densities. Univariate and multivariate analyses were performed to explore these association with histopathologic factors including histological grade.[Results] The enhancement parameters were correlated with microvessel densities (p<0.0001). The peripheral microvessel densities were significantly higher than the central microvessel densities (p<0.0001). A significant association to histological grade was observed in steepest slopes of dynamic curve and microvessel densities (p<0.05).[Conclusion] A correlation between 3-D dynamic MRI parameters and microvessel densities, and those association to histological grade were observed. This may allow MRI to be utilized for predictions of tumor angiogenesis and histological grade.

[目的]评估通过三维动态MRI获得的乳腺癌的增强特征与组织病理学的发现，尤其是肿瘤血管生成。[材料和方法]四十四个患有侵入性乳腺癌的女性接受了术攻术MR成像。以90秒的间隔（在注入GD-DTPA之前的第一个图像）以90秒的间隔（第一个图像）以90秒的间隔（GD-DTPA之前的第一个图像）获得了整个乳房（截面厚度，2 mm； gap，0 mm的三维快速射击（3D-FLASH）图像。在用抗CD34抗体染色的样品中评估了微血管密度。人相关测试用于确定增强参数和微血管密度之间关系的强度。进行了单变量和多元分析，以探索与组织学等级在内的组织病理学因素的关联。[结果]增强参数与微血管密度相关（p <0.0001）。外围微血管密度明显高于中央微血管密度（p <0.0001）。在动态曲线和微血管密度的最陡峭斜率中观察到与组织学等级的显着关联（P <0.05）。[结论] 3-D动态MRI参数与微血管密度之间存在相关性，并且观察到与组织学等级的关联。这可以使MRI用于预测肿瘤血管生成和组织学等级。