Development of nano-particles with tumor retention by single molecular DDS imaging
通过单分子 DDS 成像开发具有肿瘤保留作用的纳米颗粒
基本信息
- 批准号:20310067
- 负责人:
- 金额:$ 12.4万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To develop an effective anticancer drug, the understanding of cancer mechanisms and drug delivery system (DDS) is very important. Here, we have developed a method for in vivo imaging with very high spatial accuracy and succeeded in tracking the membrane protein PAR1 during metastasis in living mice. To investigate drug movement in association to its size in tumor, fluorescent nano-particles were injected into the tumor-bearing mice and visualized by in vivo imaging. Additionally, we developed a novel method to evaluate the structural stability and anti-cancer effect of drug-incorporating polymeric micelles.
为了开发有效的抗癌药物,对癌症机制和药物输送系统(DDS)的理解非常重要。在这里,我们开发了一种具有很高空间精度的体内成像的方法,并成功地跟踪活小鼠转移期间的膜蛋白PAR1。为了研究与肿瘤大小相关的药物运动,将荧光纳米粒子注入肿瘤的小鼠中,并通过体内成像可视化。此外,我们开发了一种新的方法来评估药物结构化聚合物胶束的结构稳定性和抗癌作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In vivo imaging of cancer metastasis with quantum dots.
使用量子点对癌症转移进行体内成像。
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Gonda K;Watanabe T.M;Takeda M;Ohuchi N;Higuchi H.
- 通讯作者:Higuchi H.
Imaging of cancer metastasis in living tumor with quantum dots
利用量子点对活体肿瘤中的癌症转移进行成像
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Gonda K;Takeda M;Kawai M Sakurai Y;Higuchi H;Ohuchi;N.
- 通讯作者:N.
In vivo single molecular imaging and sentinel node navigation by nano-technology for molecular targeting drug delivery system and tailor made medicine
通过纳米技术进行体内单分子成像和前哨节点导航,用于分子靶向药物输送系统和定制药物
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Takeda M;Tada H;Higuchi H;Kobayashi Y;Kobayashi M;Sakurai Y;Ishida T;Ohuchi N
- 通讯作者:Ohuchi N
Quantitative analysis of mechanism of cancer metastasis using in vivo nano-imaeing with quantum dots.
使用量子点体内纳米成像定量分析癌症转移机制。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Gonda K;Hikage M;Hamada Y;Takeda M. Higuchi H;Ohuchi N
- 通讯作者:Ohuchi N
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OHUCHI Noriaki其他文献
OHUCHI Noriaki的其他文献
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{{ truncateString('OHUCHI Noriaki', 18)}}的其他基金
Establishment of breast cancer screening system based on individual breast constitution
基于个体乳腺体质的乳腺癌筛查体系的建立
- 批准号:
18591428 - 财政年份:2006
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Magnetic resonance imaging of breast cancer : Correlation between contrast enhancement and tumor angiogenesis
乳腺癌的磁共振成像:对比增强与肿瘤血管生成之间的相关性
- 批准号:
10671092 - 财政年份:1998
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of breast cancer extension using new imaging technology, 3-D MRI
使用新成像技术 3-D MRI 分析乳腺癌扩散
- 批准号:
08671328 - 财政年份:1996
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Biological characteristics and therapeutic response of intraductal component of breast cancer
乳腺癌导管内成分的生物学特性和治疗反应
- 批准号:
06671178 - 财政年份:1994
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
3-D analysis of intraductal spreading of breast cancer based on expression of protooncogenes and tumor-associated antigens : Application in breast conserving surgery
基于原癌基因和肿瘤相关抗原表达的乳腺癌导管内扩散的 3-D 分析:在保乳手术中的应用
- 批准号:
04670721 - 财政年份:1992
- 资助金额:
$ 12.4万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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