Analysis of breast cancer extension using new imaging technology, 3-D MRI

使用新成像技术 3-D MRI 分析乳腺癌扩散

基本信息

批准号：
08671328
负责人：
OHUCHI Noriaki
金额：
$ 1.34万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671328/
关键词：
breast cancer breast conserving surgery intraductal spread of carcinoma magnetic resonance imaging 3-D mapping 乳房温存療法:breast conserving therapy 3次元MRI:3-D MRI 乳管内進展:intraductal spreading

项目摘要

[Introduction]Now, definition of carcinoma extension becomes more important, as breast conserving therapy is accepted as one of the treatment options. This study was initiated to clarify the ability of magnetic resonance imaging (MRI) in defining the extension of breast carcinoma, in comparison with the pathologic finding created by subserial sectioning of the specimens.[Materials and Methods]Prior to surgery the MRI was performed to 34 patients with breast cancer, then extension of tumors were 3 dimensionally assessed in maximum intensity projection (MIP). Each 3-D MIP was compared to the respective pathologic distribution of carcinoma obtained by subserial mapping.[Results and Discussion]Three imaging patterns were obtained, e.g., 1) localized (n=20), 2) segmental (n=11), and 3) random extensive (n=3) types. Among the specimens classified in localized type, 18 were defined in the TDLU,and intraductal spread of carcinoma to the nipple as long as 4 cm of extension, was observed in 2 specimens. In most of the specimens with segmental type carcinomas distributed along the duct-lobular system from the TDLU to the large duct. Clearly stained tumors in the MRI were histologically revealed to be DCIS which forms solid mass. Three were categorized as random extensive type with linear architecture, and were histologically defined to be carcinomas with diffuse stromal invasion as intraductal spread.Conventional mammography and ultrasonography underestimated carcinoma extension in 6 of the 14 patients who were categorized as segmental, or random extensive type by the MRI,suggesting that the MRI is more appropriate to estimate carcinoma distribution prior to surgery. Ten percent (2/20) of patients with localized type, however, were not visualized in the MRI.Further investigation is required to develop the diagnostic technology in clinical utilization of MRI for breast conserving surgery.

[简介]现在，随着乳房保存治疗被接受为治疗选择之一，癌癌扩展的定义变得更加重要。这项研究的开始是为了阐明磁共振成像（MRI）定义乳腺癌扩展的能力，与标本的次级外切割所产生的病理发现相比。[材料和方法]在手术之前，MRI对34例患有34例乳腺癌的患者进行了34例肿瘤的乳腺癌，然后在最大浓度中进行了肿瘤的扩展（MIP）。将每个3-D MIP与通过次级映射获得的癌的各自的病理分布进行了比较。[结果和讨论]获得了三种成像模式，例如1）局部化（n = 20），2）节段（n = 11），3）随机扩展（n = 3）类型。在局部类型分类的标本中，在TDLU中定义了18个标本，并在2个标本中观察到癌对乳头的导管内扩散为4 cm。在大多数带有节型癌的标本中，从TDLU到大型管道沿管状系统分布。在组织学上明显染色的MRI肿瘤是形成固体质量的DCI。三个被归类为具有线性结构的随机广泛类型，在组织学上定义为具有弥漫性基质入侵的致癌性，为导管内扩散。经常乳房X线摄影和超声检查低估的癌在14名患者中的6例中延伸，这些患者被分配为MRI的分段，以示为MRI，以供MRI分布，以使MRI均为MRI，以便将MRI分配给MRI。然而，在MRI中未观察到百分之十（2/20）的局部类型患者。需要进行研究，以开发MRI临床利用中MRI用于乳房保存手术的诊断技术。