Novel thermosensitive polymers obtained from N-vinylacetamide derivatives

由N-乙烯基乙酰胺衍生物获得的新型热敏聚合物

基本信息

批准号：
08651055
负责人：
AKASHI Mitsuru
金额：
$ 1.41万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

First, a series of N-vinylalkylamide with different alkyl groups was synthesized and their solution behavior in a polymeric from was examined. The free radical polymerization of N-vinylisobutyramide (NVIBA) was carried out in various solvents in the presence of a radical intiator. It was found that the polymerizability of NVIBA is similar to that of N-vinylacetamide (NVA). The resulting poly (NVIBA) showed a lower critical solution temperature (LCST) sharply at 39ﾟC.The water solubility of the resulting poly (N-vinylalkylamide) with different alkyl groups was found to vary, depending on the molecular shapes as well as the side chain length of alkyl groups. The copolymer in water showed LCSTs sharply between 10 and 90ﾟC,depending on changes in their comonomer species and its content. Then, thermosensitive monodisperse particles which consisted of polystirene core and poly (NVIBA) branches on their surface were prepared by free radical copolymerization. And slso, hydrogels prepared from VNIBA and their possible applications were also studied. The interactions between water molecules and these sythetic polymers have attached much attention. Also, the hydrated condition of these polymers were compared with that of poly (N-alkylacrylamide) derivatives by measurement of differential scanning calorimeter (DSC). As a result, aqueous poly (N-vinylalkylamide)s such as poly (NVIBA) was found to show higher LCSTs than that of aqueous poly (N-alkylacrylamide)s such as poly (N-isopropylacrylamide). We discussed the hydration of thermoseitive polymers.

首先，合成了一系列具有不同烷基的N-乙烯基烷基酰胺，并检查了来自聚合物中的溶液行为。 N-乙烯基丁酰胺（NVIBA）的自由基聚合在存在的各种溶液中进行。发现NVIBA的聚合性类似于N-乙烯酰胺（NVA）。所得的聚（NVIBA）在39℃下急剧显示出较低的临界溶液温度（LCST）。发现所得聚（N-乙烯基烷基酰胺）与不同烷基的水溶性因分子形状以及烷基长的侧链长度而变化。水中的共聚物表现出10至90 c的LCST，具体取决于其社区物种及其含量的变化。然后，通过自由自由基共聚的共聚物制备了由聚苯乙烯核心和表面上聚（NVIBA）分支组成的热敏感单分散颗粒。和SLSO，由VNIBA制备的水凝胶及其可能的应用也进行了研究。水分子与这些对称聚合物之间的相互作用引起了很多关注。同样，通过测量差异扫描量热仪（DSC）将这些聚合物的水合条件与聚（N-烷基丙烯酰胺）衍生物的水合条件进行了比较。结果，发现水（N-乙烯基烷基酰胺）S（例如聚（NVIBA））显示出比聚（N-烷基丙烯酰胺）S，例如聚（N-异丙基酯酰胺）更高的LCST。我们讨论了热聚合物的水合。