Thermosensitive polymers prepared from N-vinylacylamide

N-乙烯基酰胺制备的热敏聚合物

• 批准号: 10555326
• 负责人: AKASHI Mitsuru
• 金额: $ 7.74万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10555326/
• 关键词: thermosensitive polymers; N-vinylacylamides; N -vinylisobutyramide; poly (N-isopropylacrylamide); polymeric nanosheres; platinum colloids; DDS; LCST behavior; N-ビニルアシルアミド; 下限臨界溶解温度(LCST); ビニルアミン; 刺激応答性; 金属保護触媒; 刺激応答性高分子; ラジカル重合; 水溶性高分子; 金属

We have developed novel thermosensitive polymers consisting of N-vinylacylamides such as N-vinylisobutyramide (NVIBA) and studied their properties and application comparing with poly (N-isopropylacrylamide) (PNIPAAm). First, we synthesized N-vinylacylamide monomers and polymerized using a free radical polymerization technique. After preparing water soluble polymers and cross-linked hydrogels, their thermosensitive properties were studied in comparison with PNIPAAm. It is A found that LCST of PNVIBA is sharply 39 ℃. Dispersion copolymerization of styrene and PNIPAAm or PNVIBA macromonomers gave water dispersible core-corona type polymeric nanospheres by self-assembling mechanism. Platinum and silver colloids were effectively entrapped on the surfaces (that is corona) of thermosensitive polymeric nanospheres to act as catalyst for hydrogenation in case of platinum colloids. When peptides were physically immobilized in corona of nanospheres, this system seemed to be a well-designed oral peptide drug delivery system from the results of animal examinations. Finally, we clarified that commercially available N-vinylformamide or N-vinylacetoamide were copolymerized with vinylacetate to give thermosensitive polymers as well as PNIPAAm and PNVIBA.

我们已经开发了由N-乙烯基酰胺（例如N-乙烯基异丁胺（NVIBA））组成的新型热敏聚合物，并与聚（N-异丙基丙烯酰胺）（PNIPAAM）进行了研究和应用。首先，我们合成了N-乙烯酰胺单体，并使用自由基聚合技术进行聚合。在准备水固体聚合物和交联的水凝胶之后，与PNIPAAM相比，它们的热敏性能被研究了。发现PNVIBA的LCST急剧39℃。苯乙烯和PNIPAAM或PNVIBA宏观工具的分散共聚，通过自组装机制给出了水分散的核心型聚合物纳米球。铂和银胶体被有效地在热敏感聚合物纳米球的表面（（即电晕）上）充当铂胶体胶体的催化剂。当Petides被物理固定在纳米球的电晕中时，该系统似乎是一个精心设计的口服肽药物输送系统，从动物检查的结果中。最后，我们澄清说，将市售的N-乙烯基甲酰胺或N-乙烯酰胺与乙烯基乙酸酯共聚，以提供热敏聚合物以及PNIPAAM和PNVIBA。

项目成果

K.Suwa,K.Yamamoto,M.Akashi,K.Takano,N.Tanaka,S.Kunugi: "Effects of Salt on the Temperature and Pressure Responsive Properties of Poly(N-vinylisobutyramide)Aqueous Solution" Colloid Polym.Sci.276. 529-533 (1998)

K.Suwa，K.Yamamoto，M.Akashi，K.Takano，N.Tanaka，S.Kunugi：“盐对聚（N-乙烯基异丁酰胺）水溶液的温度和压力响应性能的影响”胶体聚合物。

F.Seto,Y.Muraoka,T.Akagi,A.Kishida,M.Akashi: "Appl.Polym.Sci.," Surface Grafting of Poly(vinylamine)onto Poly(ethylene)Film by Corona Discharge Induced Grafting, (印刷中

F.Seto、Y.Muraoka、T.Akagi、A.Kishida、M.Akashi：“Appl.Polym.Sci.”，通过电晕放电诱导接枝将聚乙烯胺表面接枝到聚乙烯薄膜上，（打印期间~

Kazuya Suzuki: "Thermo-Responsive Release From Interpenetrating Porous Silica-Poly (N-isopropylacrylamide) Hybrid Gels"J. Controlled Release. 75. 183-189 (2001)

Kazuya Suzuki：“互穿多孔二氧化硅-聚（N-异丙基丙烯酰胺）混合凝胶的热响应释放”J。

Kazuya Yamamoto: "Synthesis and Functionalities of Poly(N-Vinylalkylamide) XIII. Synthesis and Properties of Thermal and pH Stimuli-Responsive Poly (vinylamine) Copolymers"Macromolecules. 34. 8014-8020 (2001)

Kazuya Yamamoto：“聚（N-乙烯基烷基酰胺）XIII的合成和功能。热和pH刺激响应性聚（乙烯基胺）共聚物的合成和性能”大分子。

F.Seto,K.Fukuyama,Y.Muraoka,A.Kishida,M.Akashi: "Thermosensitive Surface Properties of Polyethylene Film with Poly(N-isopropyl-acrylamide)Chains Prepared by Corona Discharge Induced Grafting" J.Appl.Polym.Sci.68. 1773-1779 (1998)

F.Seto，K.Fukuyama，Y.Muraoka，A.Kishida，M.Akashi：“通过电晕放电诱导接枝制备的聚（N-异丙基丙烯酰胺）链聚乙烯薄膜的热敏表面性能”J.Appl.Polym。