Developmental Research of Learning and Adaptive Control System for Artificial Hearts

人工心脏学习与自适应控制系统的发展研究

• 批准号: 08558091
• 负责人: ABE Ken-ichi
• 金额: $ 10.24万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08558091/
• 关键词: artificial heart; control; neural control; adaptive control; learning control; optimal control; total artificial heart; artificial circulation

The purpose of this research was to develop a learning and adaptive control system of artificial hearts whose reference model is the cardiovascular center in the brain and to enable the system to carry out an artificial circulatory control, coping with the cardiovascular system whose structure and parameters are unknown and time varying.First, a control algorithm of total artificial heart (Peripheral Vascular Resistance-Based Adaptive Control ; PVRBAC) was developed. This algorithm could make the controller be reflected by the autonomic nervous system via the peripheral vascular resistance (PVR). This may be because the decoupling control is used to remove the effect of the PVR on aortic pressure. This may enable the cardiovascular center to control cardiac output by manipulating the PVR.Second, a controller for animal experiments based on the above algorithm was implemented in a personal computer system. An experimental system named effectively total artificial heart system was used to ascertain the adequacy of the PVRBAC.From this system, it could be shown that the contribution of right atrial pressure to heart rate was as good as that of aortic pressure. This implies that the PVRBAC is adequate because it uses the PVR consisting of both right atrial pressure and aortic pressure.Third, it was shown that the PVRBAC is feasible for continuous-flow artificial heart as well as pulsatile-flow one. This indicates that the PVRBAC is versatile and does not depend on the kind of blood pump or drive type.

这项研究的目的是开发人造心脏的学习和自适应控制系统，其参考模型是大脑中的心血管中心，并使系统能够进行人造循环控制，并应对其结构和参数未知并且时间变化的心血管系统。该算法可以通过周围血管阻力（PVR）通过自主神经系统反映控制器。这可能是因为使用解耦控制来消除PVR对主动脉压力的影响。这可能使心血管中心能够通过操纵PVR.second来控制心脏输出，这是一个基于上述算法的动物实验控制器，在个人计算机系统中实现了。一个指定的实验系统有效地使用了总人工心脏系统来确定PVRBAC的适当性。从该系统中，可以表明，右心房压力对心率的贡献与主动脉压力的贡献一样好。这意味着PVRBAC足够了，因为它使用了由右心房压力和主动脉压力组成的PVR。三分之一，证明PVRBAC对于连续流人工心脏以及脉冲 - 流动性是可行的。这表明PVRBAC具有多功能性，不取决于血泵或驱动器类型的种类。

项目成果

阿部裕輔: "完全人工心臓1/R制御による532日生存ヤギの長期血行動態と病態生理" 人工臓器. 26・1. 21-26 (1996)

Yusuke Abe：“使用完全人工心脏 1/R 控制存活 532 天的山羊的长期血流动力学和病理生理学”人工器官 26・1（1996）。

Akira Tanaka: "Open-loop analysis of transfer characteristics from blood pressure to heart rate using effectively total artificial heart" Proc.of 20th Annu.Int.Conf.of IEEE Eng.Med.and Biolo.454-457 (1998)

Akira Tanaka：“使用有效的全人工心脏对从血压到心率的传输特性进行开环分析”Proc.of 20th Annu.Int.Conf.of IEEE Eng.Med.and Biolo.454-457 (1998)

M.Osaka: "Mutual information discloses relationship between hemodynamic variables in artificial heart-implanted dogs" American J.Physiology. 275・44. H1419-H1433 (1998)

M.Osaka：“相互信息揭示了人工心脏植入狗的血流动力学变量之间的关系”American J.Physiology 275・44（1998）。

T.Yambe: "Spectral analysis of hemodynamics during left ventricular assistance" Int.J.Artificial Organs. 19 (6). 367-371 (1996)

T.Yambe：“左心室辅助期间血流动力学的频谱分析”​​Int.J.Artificial Organs。

T.Yambe: "Fluctuations of the hemodynamic derivatives during left ventricular assistance using oscillted blood flow" Artificial Organs. 20 (6). 637-640 (1996)

T.Yambe：“使用振荡血流辅助左心室期间血流动力学导数的波动”人工器官。