Role of growth factors and morphogens in cell differentiation

生长因子和形态发生素在细胞分化中的作用

基本信息

批准号：
08045066
负责人：
ARASE Seiji
金额：
$ 3.78万
依托单位：
The University of Tokushima, School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08045066/
关键词：
dermal papilla specific genes dermal papilla Langerhans cells allogenic blood stem cells transplant gap junction tyrosine kinase atherosclerosis TGF-beta 糖尿病トランスゼニックマウス amylin activin 同種抹消血移植毛乳頭特異的遺伝子動脈粥状変成 gap junction

项目摘要

Project activity : In 1999, Cooper visited The University of Tokushima from Jan.4 to 10. He had a close meeting mainly with Prof Itakura on collaborative research works about the roles of amylin on the pathogenesis of diabetes mellitus and schizophrenia. He also gave a lecture to medical students and postgraduate students. Arase, Itakura and Kosaka visited The University of Gackland from March 16 to 20. gave seminors to postgraduate students, then had closing meetings of this research project with all members. Finally, we decided to exchange not only research informations but also students and postgraduate students between the corresponding departments.Researctr summary : Arase has found 8 human dermal papilla specific genes and now studing functions of them by developing knock-out animals. Itakura developed both beta cells related genes' transgenic and knockout animal's to precisely elucidate functions of those gene products. Kawano and Kosaka developed peripheral blood stem cells transplantation therapy from HLA mismatched donners. They treaLed both pediatric and adult patients with haeniatological malignancies using their methods. Merriless studied the relationship between the formation of atherosclerosis and proteoglycans and found TGF-beta enhances the proteoglycans production by endothelial cells. Green found an important role of gap junction in wound healing. Cooper found a close relation between arnylin and diabctes mellitus, schizophrenia. Crosiers found knew developiriental tyrosine kinase genes and fixed their full length DNA sequence. France and Kosaka studied the relationship between premature birthand maternal serum levels of CRH, activin-A and follistatin but found no association.

项目活动：1999年，库珀（Cooper）从1月4日至10日访问了Toushima大学。他主要与Itakura教授的合作研究著作进行了一次近距离会议，介绍了梅利蛋白在糖尿病和精神分裂症的发病机理上的作用。他还向医学生和研究生进行了演讲。 Arase，Itakura和Kosaka于3月16日至20日访问了Gackland大学。为研究生提供了会议，然后与所有成员进行了该研究项目的闭幕会议。最后，我们决定不仅在相应的部门之间交换研究信息，而且还交换了学生和研究生。Researctr摘要：Arase发现了8个人类真皮乳头基因，现在通过开发淘汰动物来研究它们的功能。 Itakura开发了β细胞相关的基因的转基因和基因敲除动物，以精确阐明这些基因产物的功能。卡瓦诺（Kawano）和柯萨卡（Kosaka）从HLA不匹配的Donners出现了外周血干细胞移植疗法。他们使用其方法欺骗了患有夏还学恶性肿瘤的儿科和成年患者。 Merreless研究了动脉粥样硬化和蛋白聚糖的形成之间的关系，发现TGF-β可以通过内皮细胞增强蛋白聚糖的产生。格林发现了间隙连接在伤口愈合中的重要作用。库珀发现了精神分裂症的阿尼林和糖尿病之间有着密切的关系。 Crosiers发现知道发育型酪氨酸激酶基因并固定其全长DNA序列。法国和科萨卡研究了过早的出生和母体血清CRH，Activin-A和Follistatin之间的关系，但没有发现关联。