SYNTHESIS OF BONE THEN FILMS BY LASER ABLATION AND THEIR APPLICATIONS TO IMPLANT MATERIALS

激光烧蚀合成骨膜及其在植入材料中的应用

基本信息

批准号：
07680960
负责人：
HONTSU Shigeki
金额：
$ 1.02万
依托单位：
KINKI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

The ArF excimer laser deposition technique has been used to fabricate bioceramic hydroxyapatite (HAp) thin films. the target was the pressed pellet, that was the mixture of HAp (Ca/P=2.03) powder and P_2O_5 powder for the control the Ca/P ratio of HAp films. The bone and tooth were also used as target. The crystallized HAp films were fabricated using a after annealing method or in-situ growth method. In the case of former method, the films were deposited in vacuum in pure oxygen gas (pressure 0.4 mTorr) at substrate temperature 100ﾟC.The films were annealed for 1-10 hr at 300-550ﾟC under the oxygen+water vapor flow. The HAp films have been grown on various inorganic or organic substrates, such as Ti, Al_2O_3/Si (100) and SrTiO_3 (100) inorganic materials, and polymides (PI) and polytetrafluoroethylene (PTFE) organic materials. The mechanical properties of HAp films were examined using a dynamic ultra-micro hardness tester and an Instron testing machine. The dynamic hardness was obtained to be 390 for HAp film on Ti substrate. Also, the tensile bond strengths of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. and that of HAp film on Ti was more than 54MPa. In the case of latter method, the HAp films were deposited in vacuum in pure oxygen+water vapors (pressure 100mTorr) at temperature 450-550ﾟC.The formation of c-axis oriented HAp films has been accomplished on sapphire (0001) substrate The biocompatibility of HAp films were also studied by in-vitro experiments. In this experiment, 3T3-E1 cells were used for osteoblastic cells attachment models. As a results, the cells were attached and proliferated on the Ti substrate. This result indicate that the HAp films with laser ablation were useful for the biocompatible coating material of implant.

ARF准分子激光沉积技术Hyed to faoceramic羟基磷灰石（HAP）薄膜是HAP（CA/P = 2.03）粉末和P_2O_5粉末的混合物。使用退火方法或原位方法制造结晶的HAP膜，在以前的方法中，膜在纯氧气（压力0.4 mtorr）的底物温度下沉积在100°的纯氧气中。在300-550 ms的1-10小时上已在各种无机或有机底物上生长，例如Ti，Al_2o_3/si（100）和Srtio_3（100）和Polymides（PI）和Polytetrafluoroethere（PI）使用动态的超微型硬度测试仪检查膜，并在HAP膜上的HAP粘结强度（在Ti上的HAP胶片上）获得了390后一种方法，在温度下，在450-550的纯氧+水蒸气中，HAP膜沉积在真空中，以C轴为导向的HAP膜的变化已在Sapphire（0001）基板上通过HAP膜的生物相容性在HAP膜的生物相容性上完成体内实验。