DEVELOPMENT OF ORGANIC/INORGANIC BIOACTIVE COMPOSITE MATERIALS WITH BIOCOMPATIBILITY AND FLEXIBILITY

具有生物相容性和灵活性的有机/无机生物活性复合材料的开发

• 批准号: 10650681
• 负责人: HONTSU Shigeki
• 金额: $ 0.83万
• 依托单位: KINKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650681/
• 关键词: HYDROXYAPATITE; PULSED LASER DEPOSITION; BIOCERAMICS; IMPLANT; IN-VITRO; BIOCOMPATIBLE

The organic/inorganic bioactive composite materials should become important and useful in the medical field. The present study concerns the fabrication of crystallized hydroxyapatite [CaィイD210ィエD2(POィイD24ィエD2)ィイD26ィエD2(OH)ィイD22ィエD2 : HAp] films on polymer material substrates such as polyamides(PI), polytetrafluoroethylene(PTFE) and aramid(AM) using the ArF excimer laser deposition technique. The crystallized HAp films were fabricated using an after annealing method and were obtained on PI, PTFE and AM. The mechanical properties of HAp films on the polymer materials were examined using a peeling-off test. The tensile bond strength of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. The adhesion force between a HAp film and PTFE is very small, because PTFE is chemically stable and has an extremely low friction coefficient. An increase in the HAp/PTFE adhesion force was desirable for the surface treatment of PTFE. The surface of PTFE was modified by a sodium-naphthalene complex in a glycol ether solvent for enhanced adhesion. The tensile bond strength of HAp films on surface-modified PTFE was 6.0Mpa, which was one order of magnitude larger than that of films on non-surface-modified PTFE. The biocompatibility of HAp films on surface-modified PTFE was also studied by in-vitro experiments. In this experiment, fibroblasts cells were used for osteoblastic cells attached and proliferated on the PTFE substrate. This result indicates that the HAp films with laser ablation were useful for the biocompatible coating material of implant.

有机/无机生物活性材料表明，在结晶的羟基磷灰石中变得很重要。结晶膜是使用退火方法的，并在PI和AM上获得了HAP薄膜的机械性能。分别为9.8MPA和0.4MPA，在HAP/PTFE粘附力中，HAP膜和PTFE之间的粘附力是化学稳定的。在甘油粘附的粘附胶中，通过在表面修饰的PTFE上进行的氨基化粘结强度为6.0通过体外实验，对表面修饰的PTFE上的HAP膜的生物相容性也研究了。

项目成果

T. Matsumoto, T. Kanno, S. Hontsu, Y. Hosoi, N. Kato, K. Demizu, T. Uenoya, T. Sugimura: "Formation of Biocompatible Hydroxyapatite Thin Films Deposited by Laser Ablation"Bioceramics. 12. 499-502 (1999)

T. Matsumoto、T. Kanno、S. Hontsu、Y. Hosoi、N. Kato、K. Demizu、T. Uenoya、T. Sugimura：“通过激光烧蚀沉积生物相容性羟基磷灰石薄膜的形成”生物陶瓷。

S. Hontsu, M. Nakamori, N. kato, H. Tabata, J. Ishii and T. Kawai: "Formation of Hydroxyapatite Thin Films on Surface-Modified Polytetrafluoroethylene Substrates"Japanese Journal of Applied Physics. vol.37.No.10A. L1169-L1171 (1998)

S. Hontsu、M. Nakamori、N. kato、H. Tabata、J. Ishii 和 T. Kawai：“表面改性聚四氟乙烯基材上羟基磷灰石薄膜的形成”日本应用物理学杂志。

H. Tabata, S.Hontsu,T. Kawai: "Processing and Films Formation of biomaterials by an Excimer Laser Ablation."Journal of Japanese Society for Biomaterials. 16, No. 6. 343-349 (1998)

H. Tabata，S.Hontsu，T。

T. Matsumoto, T. kanno, S. Hontsu, Y. Hosoi, N. Kato, K. Demizu et al.: "Formation of Biocompatible Hyroxyapatite Thin Films Deposited by Laser Ablation"Bioceramics. Vol.12. 499-502 (1999)

T. Matsumoto、T. kanno、S. Hontsu、Y. Hosoi、N. Kato、K. Demizu 等人：“通过激光烧蚀沉积生物相容性羟基磷灰石薄膜的形成”生物陶瓷。

本津茂樹: "レーザーアブレーション法による生体材料薄膜の形成(未定)"レーザー研究. Vol.28.No.7. (2000)

Shigeki Mototsu：“通过激光烧蚀法形成生物材料薄膜（TBD）”Laser Research Vol.28.No.7（2000）。