DEVELOPMENT OF ORGANIC/INORGANIC BIOACTIVE COMPOSITE MATERIALS WITH BIOCOMPATIBILITY AND FLEXIBILITY

具有生物相容性和灵活性的有机/无机生物活性复合材料的开发

基本信息

批准号：
10650681
负责人：
HONTSU Shigeki
金额：
$ 0.83万
依托单位：
KINKI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

The organic/inorganic bioactive composite materials should become important and useful in the medical field. The present study concerns the fabrication of crystallized hydroxyapatite [CaィイD210ィエD2(POィイD24ィエD2)ィイD26ィエD2(OH)ィイD22ィエD2 : HAp] films on polymer material substrates such as polyamides(PI), polytetrafluoroethylene(PTFE) and aramid(AM) using the ArF excimer laser deposition technique. The crystallized HAp films were fabricated using an after annealing method and were obtained on PI, PTFE and AM. The mechanical properties of HAp films on the polymer materials were examined using a peeling-off test. The tensile bond strength of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. The adhesion force between a HAp film and PTFE is very small, because PTFE is chemically stable and has an extremely low friction coefficient. An increase in the HAp/PTFE adhesion force was desirable for the surface treatment of PTFE. The surface of PTFE was modified by a sodium-naphthalene complex in a glycol ether solvent for enhanced adhesion. The tensile bond strength of HAp films on surface-modified PTFE was 6.0Mpa, which was one order of magnitude larger than that of films on non-surface-modified PTFE. The biocompatibility of HAp films on surface-modified PTFE was also studied by in-vitro experiments. In this experiment, fibroblasts cells were used for osteoblastic cells attached and proliferated on the PTFE substrate. This result indicates that the HAp films with laser ablation were useful for the biocompatible coating material of implant.

有机/无机生物活性复合材料应在医疗领域变得重要且有用。本研究涉及结晶羟基磷灰石[CAII D210E D2（POI D24E D2）E D26E D2（OH）E D22E D2：HAP]膜上在聚合物材料材料上的膜上，例如聚酰胺（PI），Polytetrafluoroorooroorotreoorotrafluoroorooro乙烯（PI）和使用Am aramiD（ptere）和AramiD（PI）技术。使用后退火方法制造结晶的HAP膜，并在PI，PTFE和AM上获得。使用剥离测试检查了HAP膜在聚合物材料上的机械性能。 PI和PTFE上HAP膜的拉伸键强度分别为9.8MPa和0.4MPa。 HAP膜和PTFE之间的粘合力非常小，因为PTFE在化学上是稳定的，并且具有极低的摩擦系数。对于PTFE的表面处理，HAP/PTFE粘合力的增加是可取的。 PTFE的表面通过乙醚溶液中的钠萘络合物修饰，以增强粘合剂。在表面修饰的PTFE上HAP膜的拉伸键强度为6.0MPa，这比非表面修饰PTFE上的膜大的数量级。在表面修饰的PTFE上HAP膜的生物相容性也通过体外实验进行了研究。在该实验中，成纤维细胞细胞用于附着并在PTFE底物上增殖的成骨细胞。该结果表明，具有激光消融的HAP膜可用于植入物的生物相容性涂层材料。