APPLICATION OF MONOCLONAL ANTIBODY FOR THE NEW TREATMENT AND DIAGNOSIS OF DIGESTIVE CANCER.

单克隆抗体在消化道癌新治疗和诊断中的应用。

• 批准号: 07457277
• 负责人: TAKAHASHI Toshio
• 金额: $ 4.61万
• 依托单位: KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457277/
• 关键词: DIGESTIVE CANCER; MONOCLONAL ANTIBODY; CHIMERIC ANTIBODY; MICRO-FERRITE; 外科手術; 画像診断; 化学療法; 磁性鉄; 転移; 神経温存; イメージング

Huma/mouse chmeric antibody had been developed and anti-cancer drug neocarzinostatin could be bound with Fab fragment of chiemric antibody without loosing both anticancer and antibody activites. Clinical phase 1 study had been carried out and no seriouse adverse effects had been observed up to 40,000 units of immunoconojugates. The production of human anti-mouse antibody (HAMA) had been strongly suppressed in patients receiving chimeric antibody compared with patients receiving mouse immunocojugates.Fine ferromagnetics had been successfully conojugated with antibody. The stability and capacity of the cojugates to bind with target cancer cell had been well preserved. The imaging of tumor tissue in experimental animal suggested its usefullness in MRI imaging in vivo. This new ferromagnetic immunoconjugate could be applied for ferro-immuno-guided surgery in the near future.

已经开发了Huma/小鼠CHMERIC抗体，抗癌药物新可甲酸抑制素可以与Chiemric抗体的Fab片段结合而不会失去抗癌和抗体活动材料。已经进行了临床1期研究，没有观察到多达40,000辆免疫套索的严重不良反应。与接受小鼠免疫偶然的患者相比，接受嵌合抗体的患者被强烈抑制了人类抗小鼠抗体（HAMA）的产生。蛋白铁磁药已成功与抗体结合。盟友与目标癌细胞结合的稳定性和能力得到了很好的保存。实验动物中肿瘤组织的成像表明其在体内MRI成像中的有用性。这种新的铁磁免疫缀合物可以在不久的将来应用于铁免疫引导的手术。

项目成果

山口俊晴他: "消化器癌切除後の補助療法とFoLLOW-UPの実際-われわれのプロトコール胃癌" 消化器外科. 18 (3). 291-296 (1995)

Toshiharu Yamaguchi 等人：“胃肠癌切除术后的辅助治疗和 FoLLOW-UP 的实践 - 我们的胃癌方案”18 (3) (1995)。

H.Tsujimoto et al: "Amplification of c-met and K-sam genes in primary gastric canoer and peritoneal metastasis" Ist Int.Gastric canoer congress:(ed.Nishi,M.,Sugano,H.,Takahashi,T.,Monduzzi Editore,Bologna,Italy), 5 (1995)

H.Tsujimoto 等人：“原发性胃癌和腹膜转移中 c-met 和 K-sam 基因的扩增”Ist Int.胃癌大会：(ed.Nishi,M.,Sugano,H.,Takahashi,T.,

T.Yamaguchi, K.Kitamura, E.Otsuji, T.Takahashi: "Cancer missile therapy with monoclonal antibody bound with anticancer drugs." Igaku-no-ayumi.184. 325-328 (1998)

T.Yamaguchi、K.Kitamura、E.Otsuji、T.Takahashi：“使用与抗癌药物结合的单克隆抗体进行癌症导弹疗法。”

Otsuji E 他: "End result of stmulraneous splenectmy in patients undergoing total gastrectomy for gastric carcinoma" Surgery. 120. 41-44 (1996)

Otsuji E 等人：“因胃癌接受全胃切除术的患者的刺激性脾切除术的最终结果”Surgery 120. 41-44 (1996)。

山口俊晴他: "残胃癌" 消化器外科. 19 (6). 825-827 (1996)

Toshiharu Yamaguchi 等人：“残胃癌”胃肠外科 19 (6) (1996)。