Co-operative Research on Clinical Application and Functional Preservation of Heart and Heart-lung Transplantation

心、心肺移植临床应用及功能保存合作研究

• 批准号: 07307015
• 负责人: NAKAJIMA Jun
• 金额: $ 15.81万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07307015/
• 关键词: Heart Transp lantation; Organ transp lantation network; Graft atherosclerosis; Cardiomyoathy; Immunosuppression; gene transfer; donation; Cardiac xenotransplantation; 渡航心移植; 冠動脈硬化症; 補助人工心臓; Donation; 肺保存; 異種心臓移植; 心臓移植; 肺移植; 抗接着抗体; 慢性拒絶反応

Kaihara investigated information Network System for multi organ sharing and more appropriate to implement required features than a classical main frame, especially the details about handling informations on inter net system. Matsuda investigated graft coronary atherosclerosis is preset in the first several days of transplantation. Tabayashi and Isobe reported ACE inhibitor, Angiotensin II receptor antagonist, cell cycle gene decoy and anti adhesion molecule prevent graft atherosclerosis. Sano investigated the donor heart Function harvested after 1 hour of warm cardiac arrest. Taira reported feasibility of hyaluronidase fo rtified cardioplegia. Koyanagi studied new immunosuppressive agent. Kawashima and Nakatani reported two endostage cardiomyopathy cases. They were successfully treated with left ventricular assist device and still alive after weaning of the device. Furuse, Takamoto, Nakajima investigated discordant xenoheart transplantation in infantile monkeys. Hujimura, Eguchi, Yada experimentally investigated lung preservation and immunosuppressive therapy.

Kaihara 研究了多器官共享的信息网络系统，比传统的主机框架更适合实现所需的功能，特别是在互联网系统上处理信息的细节。松田研究的移植物冠状动脉粥样硬化是在移植的最初几天内预设的。 Tabayashi和Isobe报道了ACE抑制剂、血管紧张素II受体拮抗剂、细胞周期基因诱饵和抗粘附分子可预防移植物动脉粥样硬化。萨诺研究了热心脏骤停 1 小时后收获的供体心脏功能。 Taira 报告了透明质酸酶强化心脏停跳液的可行性。小柳研究了新的免疫抑制剂。 Kawashima 和 Nakatani 报告了两例末期心肌病病例。他们成功接受了左心室辅助装置的治疗，并且在撤除该装置后仍然活着。 Furuse、Takamoto、Nakajima 研究了幼猴中不一致的异种心脏移植。 Hujimura、Eguchi、Yada 通过实验研究了肺保存和免疫抑制治疗。

项目成果

Isobe M et al: "Acceptance of primary skin graft after treatment with anti intercellular adhesion molecule-1 and anti-leucocyte function associated antigen 1 monoclonal antibodies in mice" Transplantation. 62. 411-413 (1996)

Isobe M 等人：“小鼠用抗细胞间粘附分子 1 和抗白细胞功能相关抗原 1 单克隆抗体治疗后接受原代皮肤移植” 移植。

Sawa Y et al: "A norel strategy for myocardial protection using in vivo franefection of cis element ,'Decoy'against NFKB Binding Site" Circulation. 96. II-280-II-285 (1997)

Sawa Y 等人：“Norel 策略利用体内顺式元件‘诱饵’对抗 NFKB 结合位点进行心肌保护”循环。

Suzuki J et al: "Prevention of graft coronary atherosclerosis by antisense cdk2 kinase oligonucleotide" Nature Medicine. 3. 900-903 (1997)

Suzuki J 等人：“通过反义 cdk2 激酶寡核苷酸预防移植冠状动脉粥样硬化”《自然医学》。

Isobe M et al: "Acceptance of primary skin graft after treatment with anti-intercellular adhesion molocule-1 and anti-leucscyte function-associated antigen-1 monoclonal antibadies in mice" Transplantation. 62(3). 411-413 (1996)

Isobe M 等人：“在小鼠中用抗细胞间粘附分子 1 和抗白细胞功能相关抗原 1 单克隆抗体治疗后接受原代皮肤移植” 移植。

Suzuki J et al: "Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts." Circulation. 94. 1118-1124 (1996)

Suzuki J 等人：“排斥的同种异体心脏移植物中的非肌肉和平滑肌肌球蛋白重链表达。”