Assessment of Gastric Motor Function by Cine Magnetic Resonance Imaging

电影磁共振成像评估胃运动功能

• 批准号: 18591480
• 负责人: NAKAJIMA Jun
• 金额: $ 1.79万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591480/
• 关键词: MRI; gastric motility; gastric emptying; mosapride citrate; pylorus-preserving gastrectomy; 幽門保存胃切除術; 幽門輪温存膵頭十二指腸切除術; cineMRI; cine MRI; 胃蠕動運動; MRI; gastric motility; gastric emptying; mosapride citrate; pylorus-preserving gastrectomy; 幽門保存胃切除術; 幽門輪温存膵頭十二指腸切除術; cineMRI; cine MRI; 胃蠕動運動

Background and Goals: The aim of this study was to evaluate the gastric motor function by magnetic resonance imaging (MRI), and it investigated whether this examination is a useful tool for therapeutic efficacy or postoperative gastric motor function.Methods: Twenty-five healthy volunteers and 10 gastric cancer patients with pylorus-preserving gastrectomy (PPG) underwent cine-MRIs. Gastric volume was determined by 3D-volumetry. Gastric motility was quantified by calculating the gastric motility index (GMI).Results: The image acquisition and analysis were successfully performed for all subjects. In healthy volunteers, the mean frequency, amplitude, velocity of gastric peristaltic waves, and GMI 30 minutes after the intake of jelly were 3/min, 8.8mm, 2.2mm/s, and 19.6mm2/s, respectively. The mean amplitude (8.8 vs. 10.4 mm, p=0.027), velocity (2.2 vs.2.6 mm/s, p<0.001) of peristaltic waves, GMI (19.6 vs.26.7 mm2/s, p<0.001), and gastric emptying rate (18.2vs.27.5%, p=0.004) significantly increased at 30 minutes after mosapride citrate administration. PPG patients with postprandial symptoms were observed having antiperistalsis-like contraction waves and reflux of gastric contents from the pyloric region into the upper part of the stomach. The mean gastric emptying rate in PPG patients with postprandial symptoms at 30 minutes after the intake of jelly tended to be less than in those without such symptoms(9.9vs.22.1%).Conclusions: The present study demonstrates that cine-MRI is a sensitive and noninvasive imaging technique for simultaneously measuring gastric motility and emptying.

Background and Goals: The aim of this study was to evaluate the gastric motor function by magnetic resonance imaging (MRI), and it investigated whether this examination is a useful tool for therapeutic efficacy or postoperative gastric motor function.Methods: Twenty-five healthy volunteers and 10 gastric cancer patients with pylorus-preserving gastrectomy (PPG) underwent cine-MRIs.胃体积通过3D散量测定。通过计算胃运动指数（GMI）来量化胃运动性。注重：对所有受试者成功进行了图像采集和分析。在健康的志愿者中，摄入果冻摄入后30分钟的平均频率，振幅，胃蠕动速度和GMI分别为3/min，8.8mm，2.2mm/s和19.6mm2/s。蠕动波的平均振幅（8.8 vs. 10.4 vs. 10.4 vs. 10.4毫米，p = 0.027），速度（2.2 vs.2.6 mm/s，p <0.001），GMI，GMI（19.6 vs.26.7 mm2/s，s，p <0.001），以及胃清空速率（18.2vs.2vs.2vs.27.5.5％，P = 0.004） 行政。观察到餐后症状的PPG患者患有抗精性的收缩波和胃含量从幽门区域的胃含量转流到胃部的上部。果冻摄入后30分钟患有餐后症状的PPG患者的平均胃排空率往往比没有这种症状的胃清空率少（9.9vs.22.1％）。结论：本研究表明，Cine-MRI是一种敏感的和无创造的成像技术，用于同时测量气体动力和燃气动力。