Hypoxic brain damage : MR imaging findings and its correlation with histological findings

缺氧性脑损伤：磁共振成像结果及其与组织学结果的相关性

基本信息

批准号：
06670897
负责人：
TAKAHASHI Shoki
金额：
$ 1.28万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

We investigated sequential MR imaging findings of hypoxic encephalopathy and correlated them with histological findings at autopsy. We retrospectively reviewed sequential MR imaging studies of the brain in 6 patients with hypoxic brain damage. Sequential changes in signal intensity and morphological features of the brain were evaluated on repeated MR images. In the other two autopsied patientnts who had MR findings suggestive of cortical laminar necrosis, MR findings were correlated with histological findings. MR imaging was performed with a 1.5-T Magnetom H15 scanner (Siemens, Erlangen, Germany) with a head coil. T1-weighted spin-echo images, with a pulse sequence of 500/15 (repetition time [TR] msec/echo time msec) and long TR spin-echo (2500/15,90) images were obtained in the axial plane, with a 256^<**>256 matrix, a 5-10-mm section thickness, and a field of view of 20-25 cm. Occasionally, additional coronal or sagittal images were obtined. Temporal evolution of MR imaging findings … More was arbitrarily divided into frou morphological stages : acute stage, within 1 week after the onset ; early subacute stage, days 11-19 ; late subacute stage, days 21-28 ; and chronic stage, days 41 onward.Involvement of the watershed zones in the parietooccipitotemporal cortex was most frequent. Cerebral edema was seen in the acute stage. Enhanced T1-weighted images showed cortical laminar enhancement in the early subacute stage ; unenhanced T1-weighted images revealed characteristic laminar hyperintense lesions in the late subacute stage. Both of these findings reflected cortical laminar necrosis at histology. However, we could not elucidate at histological examination what caused the laminar hyperintensity on T1-weighted images. In the chronic stage, cortical atrophy and delayd but progressive white matter changes were seen. Changes in MR imaging features of hypoxic brain damage are complex but distinct. Cortical laminar necrosis and delayd white matter degeneration can be delineated. Less

我们研究了缺氧性脑病的连续 MR 成像结果，并将其与尸检时的组织学结果相关联。我们回顾性回顾了 6 名缺氧性脑损伤患者的大脑连续 MR 成像研究，评估了大脑的信号强度和形态特征的连续变化。在另外两名尸检患者中，MR 发现提示皮质层状坏死，MR 发现与组织学结果相关。使用带有头部线圈 T1 加权自旋回波图像的 1.5-T Magnetom H15 扫描仪（德国埃尔兰根西门子）进行，脉冲序列为 500/15（重复时间 [TR] 毫秒/回波时间毫秒）和长TR自旋回波(2500/15,90)图像在轴向平面上获得，具有256^<**>256矩阵，切片厚度为 5-10 毫米，视野为 20-25 厘米，有时会获得额外的冠状或矢状图像。 MR 结果成像的时间演变被任意分为形态阶段：急性阶段，在 1 以内。发病后一周；早期亚急性期，第 11-19 天；晚期亚急性期，第 21-28 天；以及慢性期，第 41 天。顶枕颞皮质分水岭区的受累最常见于急性期，增强 T1 加权图像显示早期亚急性期皮质层状强化；这两项发现都反映了组织学上的皮质层状坏死。通过组织学检查阐明导致 T1 加权图像层状高信号的原因。在慢性阶段，可以看到皮质萎缩和迟发但进行性的白质变化，缺氧性脑损伤的 MR 成像特征变化复杂但明显。迟发性白质变性可以描述较少。