Usefulness of the 3 tesla MRI in the differential diagnosis between recurrence of glioma and non-tumoral treatment related changes including radiation necrosis.

3 特斯拉 MRI 在神经胶质瘤复发和非肿瘤治疗相关变化（包括放射性坏死）之间的鉴别诊断中的作用。

• 批准号: 23591746
• 负责人: TAKAHASHI Shoki
• 金额: $ 2.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591746/
• 关键词: グリオーマ; 脳腫瘍; 放射線壊死; MRI; 灌流画像; 拡散強調画像; 潅流画像; MRスペクトロスコピー; 磁化率強調画像

We determined whether 3 tesla MRI is useful in distinguishing recurrence of glioma from post-treatment changes including radiation necrosis. MRI sequences in this study included contrast-enhanced perfusion weighted imaging (PWI), apparent diffusion coefficient (ADC), susceptibility weighted images (SWI) and MR spectroscopy (MRS). PWI with double-dosed contrast agent was robust sequence for evaluation of CBV and is useful for discrimination between recurrence of gliomas and post-treatment changes. However, bevacizumab, a newly introduced drug which reduces tumor neoangiogenesis, may underestimate CBV, leading to misdiagnose viable tumor as treatment related change. Further evaluation is needed for PWI under administration of bevacizumab. As for ADC, one of the hopeful sequences, recurrence of gliomas had a propensity to show lower ADC value than treatment related changes. SWI and MRS revealed considerable overlaps between two entities. Future quantitative analysis may be promising.

我们确定3个特斯拉MRI是否有助于区分神经胶质瘤的复发与治疗后变化，包括辐射坏死。这项研究中的MRI序列包括对比增强的灌注加权成像（PWI），明显的扩散系数（ADC），易感性加权图像（SWI）和MR光谱法（MRS）。具有双重对比剂的PWI是评估CBV的鲁棒序列，对于歧视神经胶质瘤的复发和处理后变化很有用。然而，贝伐单抗是一种新引入的药物，可降低肿瘤新血管生成，可能会低估CBV，导致随着治疗相关的变化而误诊可行的肿瘤。在贝伐单抗管理下，需要进一步评估PWI。至于ADC，这是一个希望的序列之一，胶质瘤的复发倾向于显示出比治疗相关的变化更低的ADC值。 SWI和太太揭示了两个实体之间的重叠。未来的定量分析可能是有希望的。