MRI-ASL perfusion imaging -evaluation in pediatric brain and moyamoya disease-

MRI-ASL 灌注成像 - 儿科脑部和烟雾病的评估 -

基本信息

批准号：
14570833
负责人：
TAKAHASHI Shoki
金额：
$ 2.56万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

1.Cerebral blood flow in MRI-ASL (FAIR) perfusion imaging2.SPIO Brain Perfusion Imaging : Intraindividually Controlled Randomized Crossover Comparison Study of SPIO versus GdOur results showed a clinical equivalence of perfusion imaging using SPIO and Gd.3.MRI-ASL (FAIR) perfusion imaging : Intraindividually Controlled Randomized Crossover Comparison Study of FAIR versus Gd perfusionOur results indicate that good contrast between the cortex and white matter in both FAIR and Gd perfusion. Good positive relation ship was seen between in FAIR and in the relative blood flow or blood volume in Gd perfusion (r = 0.78 and 0.448, respectively).4.MRI-ASL (FAIR) perfusion imaging in the developing brainRegional pattern of the cerebral bloofd flow derived from FAIR was similar to the PET data reported in the previous literatures, however low signal to noise ratio in FAIR image paused a problem.5.Posterior Circulation and Ischemic Stroke in Pediatric Moyamoya DiseaseOur results indicate that reduced leptomeningeal collaterals from affected posterior cerebral artery are closely related to completed strokes rather than transient ischmic attask and transdural collaterals may not be sufficient to compensate for reduced leptomeningeal collaterals. The early involvement of posterior cerebral artery in hemispheres with the less advanced internal carotid artery lesions might be resposnsible for the high prevalence of completed strokes in young children.

1.MRI-ASL (FAIR) 灌注成像中的脑血流2.SPIO 脑灌注成像：SPIO 与 Gd 的个体控制随机交叉比较研究我们的结果显示使用 SPIO 和 Gd 的灌注成像的临床等效性。3.MRI-ASL (FAIR ）灌注成像：FAIR 与 Gd 灌注的个体控制随机交叉比较研究我们的结果表明，FAIR 与 Gd 灌注之间的良好对比度FAIR 和 Gd 灌注中的皮质和白质。 FAIR与Gd灌注中的相对血流量或血容量之间存在良好的正相关关系(r分别为0.78和0.448)。 4.发育中大脑中的MRI-ASL(FAIR)灌注成像脑血流的区域模式FAIR 得出的血流与之前文献报道的 PET 数据相似，但 FAIR 图像中的低信噪比解决了一个问题。 5.后循环和缺血儿童烟雾病中的中风我们的结果表明，受影响的大脑后动脉的软脑膜侧枝循环减少与完全中风密切相关，而不是短暂性缺血性发作，并且经硬膜侧枝循环可能不足以补偿软脑膜侧枝循环的减少。半球大脑后动脉的早期受累以及较不严重的颈内动脉病变可能是幼儿完全性中风发病率较高的原因。