The featuresof rats with hypertrophic cardiomyopathy and rats with hypertension.

肥厚型心肌病大鼠和高血压大鼠的特点。

基本信息

批准号：
06670737
负责人：
NAKAGAWA Masao
金额：
$ 1.22万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

We clarified the features of rats with hypertrophic cardiomyopathy and rats with hypertension.1. The features of the coronary blood flow velocity pattern in WKY/NCrj resembled those of human hypertrophic cardiomyopathy (HCM). The abnormal pattern may relate to the abnormal course of the septal perforators.2. WKY/NCrj had the abnormal fatty acid metabolism especially in anteroseptal and in posteroseptal junction which was often seen in human HCM.This abnormality may relate to the functional disorder of mitochondria.3. We could produce the rats with cariac hypertrophy resembling human HCM morphologically and functionally by adimistering indomethacin to pregnant near-term rats.4. We have revealed by using immunohistochestry that there was primarily basic phenotype producing cardiac anomaly in WKY/NCrj. In turn, the cardiac neural crest derived from somite 1 to 3 were disturbed to migrate at 13E ; Moreover by using TUNEL method apoptotic elimination was demonstrated to be augmented in left 6th aortic arch artery at 16-17E.5. The effects of ACE Inhibitor and Angiotensin II receptor antagonist on cardiac hypertrophy, cardiac function, and coronary circulation in young SHR were assessed. Both drugs similarly prevented cardiac hypertrophy, impairment of left ventricular diastolic function, and impairment to hemodynamics of coronary blood flow in young SHR.6. The effects of ACE Inhibitor and Angiotensin II Receptor Antagoniston cardiac hypertrophy, cardiac function, and coronary circulation in old SHR were also assesseing now.

明确肥厚型心肌病大鼠和高血压大鼠的特点。 1． WKY/NCrj 的冠状动脉血流速度模式特征与人类肥厚型心肌病 (HCM) 相似。其异常形态可能与间隔穿支走行异常有关。2． WKY/NCrj存在脂肪酸代谢异常，尤其是前间隔和后间隔交界处，这在人类HCM中很常见。这种异常可能与线粒体功能紊乱有关。 3．通过给孕鼠注射吲哚美辛，可制备出形态和功能与人HCM相似的龋齿肥大大鼠。 4．我们通过免疫组织化学揭示，WKY/NCrj 中主要存在产生心脏异常的基本表型。反过来，源自体节 1 至 3 的心脏神经嵴在 13E 时迁移受到干扰；此外，通过使用TUNEL方法，证明在16-17E.5左第六主动脉弓动脉中细胞凋亡消除得到增强。评估了 ACE 抑制剂和血管紧张素 II 受体拮抗剂对年轻 SHR 心脏肥大、心功能和冠状动脉循环的影响。这两种药物同样可以预防年轻 SHR 的心脏肥大、左心室舒张功能受损以及冠状动脉血流动力学受损。6。目前也在评估ACE抑制剂和血管紧张素II受体拮抗剂对老年SHR心脏肥大、心功能和冠脉循环的影响。