New materials for artificial joint -Development of hydroxyapatite containing glass coated titanium composite-

人工关节新材料-含羟基磷灰石玻璃涂层钛复合材料的开发-

基本信息

批准号：
06559008
负责人：
IWATA Hisashi
金额：
$ 5.12万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

It is well known that the hydroxyapatite (HA) is a bioactive ceramic having excellent biocompatibility with the body environment, and that pure titanium and titanium alloy such as Ti-6Al-4V with sufficient mechanical strength are suitable metals exhibiting good biological stability and affinity. In recent years, paticular attention has been drawn to the use of HA-coated implants for hip prostheses and a dental implants in which HA layr is coated on the surface of titanium substrate by plasma spraying, sputtering, hot pressing, and laser deposition, etc. Among these techniques, plasma spraying is a method commonly used in commercial products. However'there is a problem of change of chemical composition and structure due to the themal decomposition of HA under high temperature in plasma, and the HA coating layr with more than 50 mum in thickness behave like a brittle ceramic and leads to the peeling. Furthemore, the large difference in the linear thermal expansion coeffcient between the … More HA coating layr and the titanium or Ti-6Al-4V substrate can cause fatigue failure under tensile load.From the point of view, a HA containing glass coated titanium composite (HA-G-Ti composite) was developed with newly prepared glass and conventional enameling technique without using high temperatures such as plasma spraying. This composite consists of a substrate coated with a HA containing glass layr, wherein the layr comprises a continuous glass phase with dispersed HA particles and the surface is prepared in a roughened state. It has been found that the HA-G-Ti composite provides both bioactivity potential due to the HA and the mechanical strength of titanium, and the composites are useful for biocompatible composite materials which are especially suitable for implant applications. It is demonstrated that the physical properties of the HA containing glass with different concentration of HA are suitable to constitute the HA-G-Ti composite for bioactive implant and to make an excellent adhesion between the HA containing glass and the substrate. Less

众所周知，羟基磷灰石（HA）是一种生物活性陶瓷，具有极好的生物相容性，并且具有足够的机械强度的纯钛和钛合金，例如Ti-6AL-4V，是表现出良好的生物学稳定性和亲和力的合适金属。近年来，人们注意到使用HA涂层的牙齿用于髋关节假体和牙齿牙齿，其中Ha Layr通过血浆喷涂，溅射，热压和激光沉积等在钛底物表面上覆盖，等位基因喷雾是一种通常用于商业产品中的方法。但是，由于血浆中HA在高温下HA的分解而导致的化学成分和结构的变化问题，而HA涂层则具有超过50 MM厚度的HA涂层，其厚度像脆性陶瓷，并导致脱皮。此外，…更多的HA涂层Layr和钛和Ti-6Al-4V底物之间线性热膨胀系数的巨大差异可能会在拉伸负载下引起疲劳失败。从含有HA的HA含玻璃涂层的钛合金（HA-G-TI）的玻璃涂层（HA-G-TI复合材料）与新准备好的玻璃和常规的EnmemeL频度相关。该复合材料由涂有HA的玻璃Layr的基材组成，其中Layr包含一个连续的玻璃相，带有分散的HA颗粒，表面以粗糙的状态制备。已经发现，HA-G-TI复合材料既具有HA和钛的机械强度引起的生物活性潜力，并且该组合物对于特别适合植入物应用的生物相容性复合材料有用。证明具有不同HA浓度的HA的玻璃的物理特性适合构成生物活性植入物的HA-G-TI复合材料，并在含HA的玻璃和底物之间具有出色的粘合剂。较少的