Development of stereotactic radiosurgery with the linear accelerator

直线加速器立体定向放射外科的发展

• 批准号: 06557079
• 负责人: SHIBUYA Masato
• 金额: $ 9.66万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557079/
• 关键词: Linear accelerator; Radiosurgery; Stereotactic irradiation; Brain tumor; Arteriovenous malformation

We developed a new system for stereotactic radiosurgery with the linear accelerator to treat brain diseases, such as arteriovenous malformations and brain tumors. Our system was designed to utilize preexisting linear accelerator with sufficient accuracy of radiation. This concept was to save financial cost for new installment of the system in the hospitals. Radiation of our system was done in the coronal plane of the patient's head. Multi-arc radiation was possible by moving the patient's head to the flexed or extended position without changing the plane of movement of the linear accelerator. In the conventional system, multi-arc radiation was done by moving the bed in the horizontal direction, while radiation was directed in the sagittal plane of the patient's head. Our system could do without complicated mechanisms to move the bed in the horizontal plane or wide room space for the movement.1) Linear accelerator : Digital Mevatron KD-2-50 with Power Macintosh 9500/120 was used. We confirmed that the shift of the rotation center of the linear accelerator was within 0.4mm. We are going to measure radiation dosage useing collimators in diameter of 10 and 20mm.2) The head frame for stereotactic radiosurgery was newly developed by modifying the MRI compatible head frame for the Sugita stereotactic surgery device.3) The supporting table for the head frame was newly developed.4) The computer software for calculation of the radiation plane will be developed.After the trial using animals, clinical trial is planned for the treatment of metastatic brain tumors.

我们开发了一种新的系统，用于使用线性加速器来治疗脑部疾病，例如动静脉畸形和脑肿瘤等新系统。我们的系统旨在利用足够精确的辐射精度利用现有的线性加速器。这个概念是为了节省医院新系统的经济成本。我们系统的辐射是在患者头部的冠状平面上完成的。通过将患者的头部移至弯曲或扩展位置而不改变线性加速器的运动平面，可以通过将患者的头部移至弯曲或扩展位置来进行多弧辐射。在常规系统中，通过沿水平方向移动床，而辐射则指向患者头部的矢状平面，从而完成多ARC辐射。我们的系统可以无需复杂的机制即可移动水平平面或宽阔的房间空间。1）线性加速器：使用MACINTOSH 9500/120的数字MEVATRON KD-2-50。我们确认线性加速器的旋转中心的移位在0.4mm之内。我们将测量直径为10和20mm的直径使用直径的辐射剂量。2）立体术放射外科手术的头部框架是通过修改Sugita立体定位手术设备的MRI兼容头部框架的新开发的。3）3）用于临床的临床机构。治疗转移性脑肿瘤。