Anthropomorphic motion phantom of the human fetus

人类胎儿的拟人运动幻影

• 批准号: 576599-2022
• 负责人: Sussman, DafnaD
• 金额: $ 1.46万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752536
• 关键词: Anthropomorphic; motion; phantom; human; fetus

Fetal magnetic resonance imaging (MRI) is the standard modality for accurately diagnosing fetal abnormalities. Diagnostic accuracy of fetal MRI is currently limited by artifacts caused by maternal-fetal motion, among other sources, which distort and degrade the images, inhibiting their diagnostic utility. The result is that most fetal MRI scans need to be repeated up to 4 times per patient until a clean image is obtained. This repetition is time and cost consuming for the Canadian health care system. It delays treatments, and increases the risk of fetuses being born with life-long disorders that impact their quality of life and require constant costly medical care. We urgently need fetal MRI sequences and algorithms to be developed to altogether avoid and remove the current artifacts. However, such development also requires ample and repeated testing, which is extremely time consuming and costly to do with human participants. Our solution is a device (aka phantom) that moves and looks like the human fetus within the pregnant abdomen. It forgoes the need for human volunteers for technical development, allowing to do accurate repeated testing as often and for as long as needed in one session. It promises to expedite technical development at a fraction of the current cost, while minimizing the need for repeated scans. Taken together, the fetal phantom will drastically cut down the cost of technical development as well as the cost of fetal diagnosis with MRI, thereby revolutionizing the fetal MRI field and fetal healthcare.

胎儿磁共振成像 (MRI) 是准确诊断胎儿异常的标准方法。目前，胎儿 MRI 的诊断准确性受到母胎运动等造成的伪影的限制，这些伪影会扭曲和降低图像质量，从而抑制其诊断效用。结果是，大多数胎儿 MRI 扫描需要为每位患者重复最多 4 次，直到获得清晰的图像。这种重复对于加拿大医疗保健系统来说既耗时又耗费成本。它会延迟治疗，并增加胎儿出生时患有终生疾病的风险，这些疾病会影响他们的生活质量，并需要持续昂贵的医疗护理。我们迫切需要开发胎儿 MRI 序列和算法，以完全避免和消除当前的伪影。然而，这种开发还需要大量且重复的测试，这对于人类参与者来说非常耗时且成本高昂。我们的解决方案是一种设备（又名幻影），它的移动方式和外观就像怀孕腹部内的人类胎儿。它放弃了对人类志愿者进行技术开发的需要，允许在一次会议中根据需要经常进行准确的重复测试。它有望以当前成本的一小部分加快技术开发，同时最大限度地减少重复扫描的需要。总而言之，胎儿体模将大大降低技术开发成本以及胎儿 MRI 诊断的成本，从而彻底改变胎儿 MRI 领域和胎儿医疗保健。