Research on the mother-to-infant transmission of hepatitis C virus

丙型肝炎病毒母婴传播研究

基本信息

批准号：
04304039
负责人：
SHIRAKI Kazuo
金额：
$ 8.96万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04304039/
关键词：
Hepatitis C Mother-to-infants infection Hepatitis C virus HCV RNA Vertical transmission Breast feeding HCV genotype Anti-HCV HCV亜型 C型肝炎ウイルス

项目摘要

The major route of infection by hepatitis C virus(HCV) has been blood transfusion in recent years in Japan. Mother-to-infant transmission of this virus is suspected as one of the most important routes of natural infection, but its frequency nor factors affecting this infection are not known. Since the carrier status develops even when adults are infected by HCV, which is rare by hepatitis B virus, the retrospective study of the families of HCV carriers cannot elucidate the above mentioned problems. In this research we conducted a prospective follow-up study of the infants born to the HCV carrier mothers found by screening of pregnant women.Pregnant women in six different districts of Japan were screened for serum antibody for HCV (second generation, anti-HCV) and if it was positive the serum HCV RNA was examined using polymerase chain reaction. 0.45 to 1.5% (mean 1%) of the pregnant women were positive for anti-HCV, and 71 to 76% of anti-HCV positive women were also positive for serum HCV RNA.Infants born to HCV RNA positive pregnant women were followed after birth with intervals of one to three months for more than one year after birth, examining their sera foranti-HCV, HCV RNA, as well as transaminase levels. Until now 174 infants had been followed for more than six months after birth, and six (3.4%) of them developed chronic HCV carrier status, and seven other infants showed transient infection by HCV before six months of age.Close evaluation of various factors regarding mother-to-infant infection disclosed that 1) the mothers of HCV infected infants showed higher serum HCV RNA level, and 2) most of these mothers showed apparent elevation of serum transaminase levels, but 3) no difference of infection rate was found between HCV genotypes, nor 4) between breast-fed and bottle-fed infants.

近年来，丙型肝炎病毒（HCV）的主要感染途径是输血。该病毒的母亲传播被认为是自然感染最重要的途径之一，但其频率也不是影响这种感染的因素。由于即使成年人被HCV感染，这种载体状态也会发展出来，而HCV很少受到丙型肝炎病毒的罕见，因此对HCV携带者家族的回顾性研究无法阐明上述问题。在这项研究中，我们对HCV承运人母亲出生的婴儿进行了前瞻性随访研究。筛查孕妇。日本六个不同地区的怀孕妇女因HCV（第二代，抗HCV）的血清抗体进行了筛查。如果是阳性，则使用聚合酶链反应检查血清HCV RNA。 0.45％至1.5％（平均1％）的孕妇对抗HCV呈阳性，抗HCV阳性女性的71％至76％的血清HCV RNA也为阳性。在HCV RNA阳性孕妇中出生的阳性女性在接受HCV RNA阳性孕妇。出生后一到三个月，出生后一年以上，检查其血清Foranti-HCV，HCV RNA以及转氨酶水平。到目前为止，在出生后已有174名婴儿六个月以上，其中6个（3.4％）发展出慢性HCV携带者状态，其他7名婴儿在六个月之前通过HCV表现出暂时感染。母亲到感染的感染揭示了1）HCV感染婴儿的母亲表现出较高的血清HCV RNA水平，2）这些母亲中的大多数表现出明显的血清转氨酶水平升高，但3）没有发现HCV之间的感染率差异。基因型，4）在母乳喂养和奶瓶喂养的婴儿之间。