A prospective study on the mother-to-infant transmission of hepatitis C virus and the prognosis of the infected infants.

丙型肝炎病毒母婴传播及感染婴儿预后的前瞻性研究。

基本信息

批准号：
06304031
负责人：
SHIRAKI Kazuo
金额：
$ 2.11万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06304031/
关键词：
Hepatitis C Mother-to-infants infection Hepatitis C virus HCV RNA Vertical transmission Breast feeding HCV genotype Anti-HCV

项目摘要

Mother-to-infant transmission of hepatitis C virus (HCV) is suspected as one of the most important routes of natural infection of this virus, but its frequency nor factors affecting this infection are not known. Since the carrier status develops even when adults are infected by HCV,which is rare by hepatitis B virus, the retrospective study of the families of HCV carriers cannot elucidate the above mentioned problems. In this research we conducted a prospective follow-up study of the infants born to HCV carrier mothers found by screening or pregnant women.Pregnant women in six different districts of Japan were screened for serum antibody for HCV (second generation, anti-HCV) and if it was positive the serum HCV RNA was examined using polymerase chain reaction. 0.45 to 1.5% (mean 1%) of the pregnant women were positive for anti-HCV,and 71 to 76% of anti-HCV positive women were also positive for serum HCV RNA.Infants born to anti-HCV positive pregnant women were followed after birth with intervals of one to three months for more than one year after birth, examining their sera for anti-HCV,HCV RNA,as well as transaminase levels. Until now 325 infants had been followed for more than six months after birth, and seventeen of them developed chronic HCV carrier status, all of whom were the products of HCV-RNA positive mothers, and none of the infants born to HCV RNA negative mothers showed the sign of HCV infection. The mean percentage of the development of HCV carrier status was 5.4% among the infants born to HCV RNA positive mothers. There were seven other infants who showed transient infection by HCV before six months of age.Close evaluation of various factors regarding mother-to-infant infection disclosed that 1) the mothers of HCV infected infants showed higher serum HCV RNA level, but 2) no difference of infection rate was found between HCV genotypes, 3) between the density gradient status of virus particles in sera, nor 4) between breast-fed and bottle-fed infants.

认为丙型肝炎病毒（HCV）的母亲到侵入的传播被认为是该病毒自然感染最重要的途径之一，但其频率也不是影响这种感染的频率。由于即使成年人被HCV感染，这种载体状态也会发展出来，而HCV很少受到丙型肝炎病毒的罕见，因此对HCV携带者家族的回顾性研究无法阐明上述问题。在这项研究中，我们对筛查或孕妇发现的HCV承运人母亲出生的婴儿进行了前瞻性随访研究。日本六个不同地区的怀孕妇女因HCV（第二代，抗HCV）和如果是阳性，则使用聚合酶链反应检查血清HCV RNA。 0.45至1.5％（平均1％）的孕妇对抗HCV呈阳性，抗HCV阳性女性的71％至76％的血清HCV RNA也为阳性。出生后出生后一到三个月，出生后一年以上，检查其抗HCV，HCV RNA以及转氨酶水平的血清。到目前为止，有325名婴儿出生后六个月以上，其中有17例患有慢性HCV载体状态，所有这些都是HCV-RNA阳性母亲的产物，而HCV RNA负面母亲所生的婴儿都没有显示出来HCV感染的迹象。 HCV RNA阳性母亲出生的婴儿的HCV载体状况的平均百分比为5.4％。还有其他七个婴儿在六个月大之前通过HCV表现出瞬时感染。对母亲到感染感染的各种因素的评估披露，1）HCV感染的婴儿的母亲表现出较高的血清HCV RNA水平，但2）否在HCV基因型之间发现感染率差异，3）在血清中病毒颗粒的密度梯度状态之间，而4）在母乳喂养和奶瓶喂养的婴儿之间。