Intrinsic control of cerobro-vascular tone-role of central nor-advenergic system

中枢去甲肾上腺系统脑血管张力作用的内在控制

基本信息

批准号：
03670690
负责人：
MAEDA Minoru
金额：
$ 1.28万
依托单位：
Juntendo University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

We have investigated the role of the central dorsal and rentral noradrenergic systems (Locus Coeruleus Complex, LC, Medullary Reticular Formation, MRF) and the cholinoceptive pontine area (CPA) in control of cerebral vasomotor tone. The experiments were performed on 30 chloralose-anesthetized cats with or without Kaolin induced hydrocephalus.[I] Microinjection of glutamate or carbochol into the LC or the MRF induced decrease of ICP in association with a slight rise of BP.On the other hand microinjection of carbachol or Ach into the CPA produced "plateau wave" like ICP-variations.[II] Tonic discharges of the LC neuron were gradually suppressed at 10 to 30 sec. prior to the onset of plateau waves, almost completely silenced during the plateau phase. Tonic MRF-neuron discharges were gradually suppressed about 30 sec. before onset o fplateau wave like ICP-variations and sharply suppressed during the plateau phase. Recovery began 10 to 30 sec. before the ICP decrease. On the other hand, the firing rate of the CPA-neuron was increased in phase with the plateau waves.[III] Electrophysiological studies show that the CPA neurons suppress both the LC and MRF-neurons which make up the central noradrenergic system. Activation of the CPA neurons should suppress activity in the central noradrenergic system. The increase in CBV then occurrs in response to dilatation of cerebral vessels.These results suggest that activity within the CPA, LC and MRF contributes to ICP changes and is the endogenous neuronal origin of plateau waves occurring in some conditions such as Kaolin induced hydrocephalus.

我们已经研究了中央背侧和租赁去甲肾上腺素能系统（locus coeruleus complex，LC，髓质网状形成，MRF）和胆碱感应性蓬托区（CPA）在控制脑血管运动器张力中的作用。对30只氯糖 - 麻醉的猫进行了实验ICP变化。[ii] LC神经元的滋补术在10到30秒时逐渐抑制。在高原波发作之前，在高原阶段几乎完全沉默。滋补MRF-Neuron排放逐渐抑制约30秒。在发作之前，fplateau波像ICP变体一样，在高原阶段被抑制。恢复开始了10至30秒。在ICP减少之前。另一方面，与高原波相阶段增加了CPA-Neuron的发射速率。[iii]电生理研究表明，CPA神经元抑制了构成中央甲肾上腺素能系统的LC和MRF-神经元。 CPA神经元的激活应抑制中央甲肾上腺素能系统的活性。然后，由于脑血管扩张而发生CBV的增加。这些结果表明，CPA，LC和MRF内的活性会导致ICP变化，并且是高原波的内源性神经元起源，例如在某些情况下，例如高岭土诱导的脑积水。