Roles of neuro-endocrine systems in the brain-immune interaction.

神经内分泌系统在脑免疫相互作用中的作用。

• 批准号: 03044115
• 负责人: HORI Tetsuro
• 金额: $ 4.35万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03044115/
• 关键词: brain-immune interaction; splenic sympathetic nerve; cytokine; interferon-alpha; interleukin-1; splenic NK activity; circumventricular organ; prostaglandin E2; 視床下部CRF; インターフェロン; インターロイキン1; 下垂体・副腎皮質系; 視床下部・内分泌系; CRF; バソプレッシン

The aim of this project was to elucidate roles of hypothalamus-endocrine and autonomic axis in neuroimmunomodulation. We investigated mechanisms of central interferon-alpha-induced immunosuppression and a part of the results was presented by a member of this project, Dr.T.Katafuch, at 2nd international congress of neuroimmunomodulation at Paestum, Italy (September, 1993).After the congress, he visited Max-Planck-Institute, and discussed with Drs.Simon and Riedel. In September 1993, Dr.Riedel visited our laboratory to present his results and to discuss with us. The details of the results of this project are as follows.1)Microinjection of interferon-alpha (IFN-alpha) into the preoptic/anterior hypothalamic area (POA), but not into other hypothalamic nuclei, resulted in a marked decrease in the splenic natural killer (NK) cell activity. The suppression was completely blocked by splenic denervation.2)Microinjection of IFN-alpha into the POA, but not into the paraventricular nucleus (PVN), … More produced an increase in the splenic nerve activity for more than 1 hour. However, CRF was effective in increasing the nerve activity when injected into both POA and PVN.3)Intraventricular injection of interleukin-1beta(IL-1beta) induced a prolonged increase in the splenic nerve activity, which was blocked by pretreatment with alpha-MSH. In addition, pretreatment with salicylate completely blocked the IL-1beta induced activation of the nerve activity.4)All neurons which antidromically responded to stimulation of POA or PVN altered their firing rates following intravenous injection of IL-1beta. These responses to IL-1beta were attenuated by iontophoretic application of salicylate, suggesting a local synthesis of prostadrandins following systemic IL-1beta which would change the firing rates of the neurons.5)Application of PACAP to the magnocellular neurons in the PVN resulted in an increase in firing rate in a dose-dependent manner. This finding may explain a possible mechanism for PACAP-induced secretion of vasopressin. Less

这是阐明下丘脑 - 内态轴在神经免疫调节中的作用。意大利Paestum（1993年9月）。他在1993年9月与Max-Planck-Ind访问了Max-Planck-Ind最多的项目如下-Alpha进入POA，但没有进入旁脑膜核（PVN），...更多的是脾神经增加了1个以上，CRF有效地增加了神经在poand n.3）中的神经，将脑介入内脑内肠内静脉内静脉内静脉内 - 1beta（IL-1Beta）诱导脾神经活性的长时间增加，这是通过用α预处理的。 POA或PVN在静脉注射IL-1BETA后改变了他们的发射，这些对IL-1Beta的反应是通过prostadrandins的水杨酸盐SIS衰减的。 pVN中的PACAP与pVN中的磁性神经元的摄入率较小

项目成果

Hori,T.: "Neural modulation of immunity:hypothalamic and peripheral autonomic neuronal mechanisms.In New Trends in Autonomic Nervous System Research.(Eds.M.Yoshikawa et al)" Elsevier Sci.Publ.,Amsterdam, 623 (1991)

Hori,T.：“免疫的神经调节：下丘脑和周围自主神经元机制。自主神经系统研究的新趋势。（Eds.M.Yoshikawa 等人）”Elsevier Sci.Publ.，阿姆斯特丹，623（1991）

Hori,T.: "Effects of temperature and neuroactive substances on hypothalamic neurones in vitro:Possible implicatin for the induction of fever." Physiological Research. 41. 77-81 (1992)

Hori,T.：“温度和神经活性物质对体外下丘脑神经元的影响：可能与诱导发烧有关。”

堀哲郎: "「Ammusl Review 免疫 1992」(菊池浩吉、矢田純一、奥村康編)"免疫系-神経系相互作用"(165-174頁)" 中外医学社, 289 (1992)

Tetsuro Hori：“Ammusl Review Nutrition 1992”（由 Kokichi Kikuchi、Junichi Yada 和 Yasushi Okumura 编辑）“免疫系统-神经系统相互作用”（第 165-174 页），Chugai Igakusha，289（1992）

Take,S.: "Central interferon alpha suppresses the cytotoxic activity of natural killer cells in the mouse spleen." Ann.N.Y.Acad.Sci.650. 46-50 (1992)

Take,S.：“中央干扰素α抑制小鼠脾脏中自然杀伤细胞的细胞毒活性。”

Take,S.: "Central interferon α inhibits the natural killer cytotoxicity through sympathetic innervation." Am.J.Physiol.265. R453-R459 (1993)

Take, S.：“中枢干扰素 α 通过交感神经支配抑制自然杀伤细胞毒性。”Am.J.Physiol.265 (1993)。