Contral co-crdination of different homeostatic functions and hyppothalamic peptides.

不同稳态功能和下丘脑肽的控制协调。

基本信息

批准号：
61480114
负责人：
HORI Tetsuro
金额：
$ 4.35万
依托单位：
Saga Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

Responsiveness of hypothalamic thermsensitive neurons to non-thermel homeostatic parameters and hypothalamic peptides was studied in anesthetized rats of in the rat's hypothalamic tissue slices in vitro. 1) Many (60-70 %) thermosensitive neurons, but not non-thermosensitive neurons, were found to teceive afferent inputs from baro/volume receptors in the circulatory control and also from peripheral osmoreceptors. Furthermor, similar proportions of thermosensitive neurons were directly osmosensitive. These findings may emplain the reduced thermoregulation during hypohydration and the hypothermia after acute blood loss, both of which have been generally recognized to be the abaptive responses in conflicting situations created by thermoregulatory drives and osmoregulatory of circulatory drives. 2) Angiotensin II and vasopressin, both having roles in osmoregulation and circulatory regulation, activated and depressed warm-sensitive neurons and cold-sensitive neurons, respectively. The respon … More ses are compatible with the hypothermia induced by these peptides. 3) peptides having profound effects on the energy metabolism (bombesin, neurotensin and TRH) affected the activity of hypothalamic thermosensitive neurons appropriately, explaining the poikilothermia and decreased metabolism induced by bombesin and neurotensin and the hyperthermia and increased metabolism by TRH. 4) Muramyl peptide, interleukin-1 and interferon <alpha>, all of which induce fever, sleep and anorexia, depressed and excited warm-sensitive neurons and coldsensitive neurons respectively. Interleukin-1 and interferon<alpha> also incresaed the activity of glucosensitive neurons in the entromedial hypothalamus. 5) The results suggest the coordination of different homeostatic function may be achieved partly by the multiple responsiveness of hypothalamic neurons th different ferent homeostatic parameters and partly by the actions of hypothalamic peptides having the roles in the control of different functions on the neurons, in addition to the mutual neuronal connections among different homeostatic control systems. Less

在体外麻醉大鼠的下丘脑组织切片中研究了下丘脑热敏神经元对非热稳态参数和下丘脑肽的反应性1)发现了许多(60-70%)热敏神经元，但没有发现非热敏神经元。接收来自循环控制中的压力/容量感受器以及外周的传入输入此外，相似比例的热敏感神经元对渗透敏感，这些发现可能解释了缺水期间的温度调节降低和急性失血后的体温过低，这两种情况都被普遍认为是由温度调节驱动力和热调节力造成的冲突情况下的适应性反应。 2) 血管紧张素 II 和加压素，均在渗透压调节和循环调节中发挥作用，激活和抑制。分别对热敏感神经元和冷敏感神经元的反应与这些肽引起的低温相容。3) 对能量代谢有深远影响的肽（铃蟾肽、神经降压素和TRH）影响下丘脑热敏感的活性。神经元适当地解释了由铃蟾肽和神经降压素引起的体温过低和代谢减少以及 TRH 4) Muramyl 肽引起的体温过高和代谢增加。白细胞介素-1和干扰素<α>，它们都会引起发热、睡眠和厌食，分别抑制和兴奋热敏感神经元和冷敏感神经元。5)结果表明，不同稳态功能的协调可能部分是通过多重因素实现的。下丘脑神经元对不同稳态参数的反应性和部分除了不同稳态控制系统之间的相互神经元连接之外，还通过下丘脑肽的作用来控制神经元的不同功能。