Establishment of estimating method of the brain function by near infra-red light computed tomography and its application

近红外光计算机断层扫描脑功能评估方法的建立及其应用

基本信息

批准号：
02557014
负责人：
NAKAGAWA Hachiro
金额：
$ 8.38万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

1. Measurement by body oxygen monitoring apparatusUnder anesthesia and artificial breathing, absorption of near infra-red light (600-1000 nm) was measured before and after the ischemic condition in the head. It was found that the deoxygenated form of hemoglobin increased after the ischemic condition. We observed a change in the absorption indicating that the administration of a brain blood flow improving drug caused an increase in the hemoglobin content in the brain.2. Measurement by near infra-red light CT apparatusThe near infra-red light CT apparatus was made using semiconductor laser near infra-red lights (780 nm, 805 nm and 830 nm) and photomultipliers. Using this apparatus following results were obtained. (1) Resolution. Measuring the absorption of different phantoms which had 10 mm sqaure surface, it was found that the limit of the resolution of this apparatus was less than 10 mm. (2) CT image of rat abdomen. When CT image was obtained by the absorption of the light of 780 nm, t … More he resolution was not good because of the surface reflection and edge amplification. Thus, the image was made by the difference between absorptions at 780 nm and 805 nm, and the image of the left lobe of the liver was successfully obtained. (3) CT image of rat brain. Under the ischemic condition, the blood was exchanged for an artificial plasma and images of brain and muscles in the head using the difference between absorptions at 780 nm and 805 nm (this yields mainly informations about oxygenation of hemoglobin and hemoglobin content) was successfully obtained. Images of brain and muscles in the head using the difference between absorptions at 805 nm and 830 nm (this yields mainly the information about reduction of cytochrome oxidase) was successfully obtained under a condition of inspiring air with low oxygen concentration and hypoglycemia after exchanging blood for artificial plasma. These findings indicate the possibility that the blood content, oxygen concentration and oxidoreductive condition of cytochrome oxidase can be measured by near infra-red light CT apparatus. Less

1。通过体内氧气监测的测量和人工呼吸，在头部缺血状态之前和之后测量了近红外光（600-1000 nm）的抽象。发现缺血性病后血红蛋白的脱氧形式增加。我们观察到荒谬的变化，表明脑血流改善药物的给药会导致大脑中血红蛋白含量的增加。2。通过近红外光CT设备进行测量，近红外光CT设备是使用近红外灯（780 nm，805 nm和830 nm）和光电塑料的半导体激光器进行的。使用此设备以下结果。（1）分辨率。测量具有10 mm平方表面的不同幻像的抽象，发现该设备的分辨率的极限小于10 mm。（2）大鼠腹部的CT图像。当通过吸收780 nm的光获得CT图像时，由于表面反射和边缘扩增，他的分辨率不佳。这是由780 nm和805 nm处的施虐者之间的差异以及肝脏左叶的图像成功获得的。（3）大鼠大脑的CT图像。在缺血性的情况下，使用780 nm和805 nm的遗憾之间的差异改变了人造等离子体的血液和头部大脑和肌肉的图像（这主要是关于血红蛋白和血红蛋白含量的氧合的信息）。在805 nm和830 nm处的遗憾之间的差异（这主要是氧化细胞色素减少的信息）在启发氧气浓度低和低血糖的人工等血浆后成功地获得了头部大脑和肌肉的图像。这些发现表明，可以通过接近红外光CT设备来测量细胞色素氧化物的血液含量，氧气浓度和氧化剂条件。较少的