The Development of ESR-CT Apparatus for Biological Samples and the Application to Diagnosis of Intractable Diseases such as Tumor

生物样本ESR-CT仪的研制及其在肿瘤等疑难杂症诊断中的应用

• 批准号: 01870113
• 负责人: KOBAYASHI Tadashi
• 金额: $ 1.41万
• 依托单位: Hokuriku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B).
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01870113/
• 关键词: ESR-CT; ESR Imaging; Mri; Melanin; Melanoma; Alanine; Imaging Plate; Image Processing; 誘電体共振器; ピンホ-ル共振器; TMモ-ド共振器

We have developed several X-band ESR-CT (ESR Imaging ) Apparatus and automatically measured by using a personal computer through the GP-IB interface bus shown as follows.(1) ESR imaging apparatus with a pin-hole TE_<102> mode cavity and a rapid scan coil.(2) ESR CT apparatus with a thin TM_<110> mode cavity and 3-dimensional ESR imaging coils.(3) ESR CT apparatus with a small TM_<01> delta mode cavity and ESR imaging coils.(4) convenient and educational 3-dimensional ESR-CT apparatus.Using these apparatus, ESR imaging of melanin in mouse B16 melanoma was observed for the first time. Three dimensional ESR imaging plates of alanine and sucrose (cane sugar) have been developed as dosimeters and applied to measure how much radioactivity is received.

我们开发了多款X波段ESR-CT（ESR成像）设备，并通过GP-IB接口总线使用个人计算机进行自动测量，如下所示。（1）针孔TE_<102>模式ESR成像设备(2) 具有薄 TM_<110> 模式腔和 3 维 ESR 成像线圈的 ESR CT 设备。(3) 具有小型 TM_<01> 的 ESR CT 设备δ模式腔和ESR成像线圈。（4）方便且具有教育意义的3维ESR-CT设备。使用该设备，首次观察到小鼠B16黑色素瘤中黑色素的ESR成像。丙氨酸和蔗糖（蔗糖）的三维 ESR 成像板已被开发为剂量计，并用于测量接收到的放射性量。

项目成果

Hiroyuki Horiuchi: "TimeーofーFlight Pulsed Neutron Diffraction Study on Uniaxial StressーInduced Domain Switching of LaNbO_4" Jpn.J.Appl.Phys.

Hiroyuki Horiuchi：“LaNbO_4 单轴应力诱导域切换的飞行时间脉冲中子衍射研究”Jpn.J.Appl.Phys。

Hiratoshi KATSUDA: "Electron Spin Resonance Imaging of B16 Melanoma" Chemical&Pharmaceutical Bulletin.

Hiratoshi KATSUDA：“B16 黑色素瘤的电子自旋共振成像”化学

T. Kobayshi: "Development of ESR Imaging Apparatus (ESR Microscope) using Dielectric Resonator" Report of Shimazu Science Foundation. 46-50 (1988)

T. Kobayshi：“使用介质谐振器开发ESR成像设备（ESR显微镜）”岛津科学基金会的报告。

Hiratoshi Katsuda: "Electron Spin Resonance Imaging of Mouse B16 Melanoma" Chem.Pharm.Bull.38. 2838-2840 (1990)

Hiratoshi Katsuda：“小鼠 B16 黑色素瘤的电子自旋共振成像”Chem.Pharm.Bull.38。

T. Kobayashi and H. Katsuda: "Development of ESR Apparatus for Single Crystal ESR Analysis and Application to Single Crystal ESR Dating" CHIKYU MONTHLY. 12 (No. 2). 65-69 (1990)

T. Kobayashi 和 H. Katsuda：“用于单晶 ESR 分析的 ESR 装置的开发及其在单晶 ESR 测年中的应用”CHIKYU MONTHLY。