An experimental study on histopathological changes of alveolar bone around hydroxyapatite during orthodontic tooth movement.

正畸牙移动过程中羟基磷灰石周围牙槽骨组织病理学变化的实验研究。

基本信息

批准号：
62570858
负责人：
HARA Yoshitaka
金额：
$ 1.34万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

It the been unclear whether M.T.M. is acceptable in the cases treated with bone graft using hydroxyapatite(HAP), which is not bio-degradable. So we examined histological changes of bone among HAP during orthodontic tooth movement. HAP was implanted into artificial bone defects adjacent to second premolars in beagie dogs, and as control no materials was implanted into them. Three months after implantation, the second premolars were moved with orthodontic force. Then they were observed histopathologically. The results obtained were as follows.Amount of movements of the teeth in implanted sites were smaller than control. At pressure zone : Resorptions of bone by osteoclasts were observed both in implanted and control sites, in addition, root resorptions occured adjacently to HAP. Further mutinucleated giant cells closely attached to HAP surrounded by bone and connective tissue. In retention period there was ankylosis between roots and bone around HAP. At tension zone : additional bone from HAP was observed. Bone defects were filled with bone in implanted sites, on the other hand, with connective tissue in control.These results suggested that bone among HAP was resolved by osteoclasts. Clinically, HAP implantation for pressure zone should be avoided because of the occurence of root resorption and ankylosis. But for tension zone it seems to be effective because HAP implantation produces more repaired bone.

目前尚不清楚M.T.M.是否在使用羟基磷灰石（HAP）处理的情况下，可以接受，这是不可生物降解的。因此，我们检查了正畸牙齿运动过程中HAP中骨骼的组织学变化。将HAP植入了Beagie Dogs的第二前期前磨牙附近的人造骨缺陷中，并且由于对照没有任何材料植入其中。植入三个月后，第二个前磨牙用正畸力移动。然后从组织病理学上观察到它们。所获得的结果如下。植入部位中牙齿运动的运动小于对照。在压力区域：在植入部位和对照部位观察到骨骼骨骼的骨骼，此外，还发生了与HAP相邻的根系解析。进一步连接的巨型细胞紧密连接到被骨和结缔组织包围的HAP。在保留期间，HAP周围的根和骨之间存在强化性。在张力区：观察到HAP的其他骨头。另一方面，植入部位的骨骼缺陷充满了骨骼缺陷，结缔组织在控制中。这些结果表明HAP之间的骨头是通过破骨细胞解决的。在临床上，由于根部吸收和障碍症，应避免避免使用压力区的HAP植入。但是对于张力区来说，这似乎是有效的，因为HAP植入会产生更多修复的骨骼。