Substituted polyhydroquinolines from amino acids as templates for medicinal chemistry applications

氨基酸取代的聚氢喹啉作为药物化学应用的模板

• 批准号: 543675-2019
• 负责人: Bélanger, Guillaume
• 金额: $ 0.85万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699671
• 关键词: Substituted; polyhydroquinolines; amino; acids; templates

The objective of the current project is to develop a rapid and efficient preparation of a library of aza-bicyclic compounds that are functionalized cores of different families of natural alkaloids. Such compounds are among privileged structures that are underexploited by the pharma industry as drug candidates. They are also recognized to improve clinical success of medicinal chemistry programs. The present proposal is an ideal match between private and academic interests: we will expand fundamental science by exploring the scope of a methodology that has just been developed, and the compounds will be used to increase chances of success of drug discovery programs run at Paraza Pharma. Such project will benefit Canadians by strengthening a leading employer and by forming highly qualified researchers, in addition to the impact on Canadian's health from eventual therapies that could come out of this research.

当前项目的目标是开发一种快速有效的制备方法来制备氮杂双环化合物库，这些化合物是不同天然生物碱家族的功能化核心。此类化合物属于特权结构，但制药行业尚未充分利用它们作为候选药物。它们还被认为可以提高药物化学项目的临床成功率。目前的提案是私人和学术利益之间的理想匹配：我们将通过探索刚刚开发的方法的范围来扩展基础科学，这些化合物将用于增加 Paraza Pharma 运行的药物发现项目的成功机会。除了这项研究可能产生的最终疗法对加拿大人健康的影响之外，该项目还将通过加强领先雇主和培养高素质研究人员来使加拿大人受益。