Development of the artificial bone for diagnosis

用于诊断的人造骨的开发

• 批准号: 60570483
• 负责人: MATSUNO Takashi
• 金额: $ 0.77万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570483/
• 关键词: Bone Phantom; Artificial Bone; Bone Mineral; Microcapsule; CT-value; CT-scanner; Inorganic Wall Microcapsule; 骨塩定量

Computed tomography is a method for noninvasive assessment of bone mineral content. This method needs calibration phantoms. In this study, the calibration bone phantoms were made by the compression molding(20 t/ <cm^2> ) of multicore microcapsules or inorganic wall microcapsules( <I> and <II> -types) prepared. The multicore microcapsules were gelatin spheres of 0.5-2.0 mm diameters containing many titanium dioxide particles(rutile type, diameter: 0.3 <micro> m). <I> -type inorganic wall microcapsules were prepared by blending the titanium dioxide particles and nylon 12 microspheres(diameter: 5.0 <micro> m) at room temperature for 60 min with an automatic ceramic mortar and stirrer. <II> -type inorganic wall microcapsules were prepared by an impact type hybridization machine. The impacting pressure drives the titanium dioxide particles into nylon 12 microsphere surfaces and the resulting microcapsules are made up of inorganic compound(wall material) and organic compound(core material). The ratio of the inorganic compound to the organic compound can be arbitrarily controlled by changing the mixing ratio of both compounds. The materials developed in this study make possible to prepare the bone phantoms having arbitrary CT-values. The bone phantoms obtained were extremely homogeneous in regard to X-ray absorption and seemed very useful for evaluation the bone mineral content.

计算机断层扫描是一种无创评估骨矿物质含量的方法。此方法需要校准幻象。在这项研究中，校准骨幻像是由编制的多核微胶囊或无机壁微胶囊（<i>和<ii>型）的压缩成型（20 t/ <cm^2>）制成的。多核微胶囊是直径为0.5-2.0 mm的明胶球，其中包含许多二氧化钛颗粒（金红石类型，直径：0.3 <micro> m）。通过将二氧化钛颗粒和尼龙12微球（直径：5.0 <micro> m）在室温下60分钟与自动陶瓷砂浆和搅拌器混合，制备<i>型无机壁微胶囊。 <ii> - 型无机壁微胶囊是通过撞击型杂交机制备的。影响压力将钛二氧化钛颗粒驱动到尼龙12微球表面，所得的微胶囊由无机化合物（壁材料）和有机化合物（核心材料）组成。无机化合物与有机化合物的比率可以通过更改两种化合物的混合比来任意控制。这项研究中开发的材料使得准备具有任意CT值的骨幻像。对于X射线吸收而言，获得的骨幻像非常均匀，似乎对于评估骨矿物质含量非常有用。

项目成果

Masumi Koishi: "Preparation and surface properties of encapsulated powder pharmaceuticals" Proceedings of the 4th International Conference on Pharmaceutical Technology. 5. 205-213 (1986)

小石真澄：“胶囊粉末药物的制备和表面特性”第四届国际制药技术会议论文集。

松野昂士: 材料技術. 5. (1987)

松野浩二：材料技术 5。（1987）

Takashi Matsuno: "Preparation and evaluation of bone phantoms for determining bone mineral content" Zairyo Gijutsu. 5. (1987)

Takashi Matsuno：“用于测定骨矿物质含量的骨模型的制备和评估”Zairyo Gijutsu。

Masumi Koishi: Proceedings of the 4th International Conference on Pharmaceutical Technology. 5. 205-213 (1986)

Masumi Koishi：第四届国际制药技术会议论文集。

Masumi Koishi: Chimica oggi.

小石真澄：Chimica oggi。