Bacteriological study of therapy-resistant periapical periodontitis

难治性根尖周炎的细菌学研究

• 批准号: 09671975
• 负责人: YOSHIDA Masahiro
• 金额: $ 0.64万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671975/
• 关键词: therapy-resistant periodontitis; chair-side incubation system; Peptostreptococcus; Actinomyces; Enterococcus; Staphylococcus; Enterobactor; Candida; 偏性嫌気性菌; 通性嫌気性菌; 真菌; 細菌感染

The bacteria in root canals of 32 cases diagnosed as therapy-resistant periapical periodontitis based on clinical progress were studied using chair-side anaerobic incubation system.All the case of therapy-resistant periapical periodontitis is cultivation positivities. This shows that therapy-resistant periapical periodontitis is an infectious disease.Peptostreptococcus and Actinomyces of anaerobes, Enterococcus, Staphylococcus and Enterobactor of facultatives, and Candida of fungus were isolated predominantly. Infection by these microbes may have play the significant role in formation of therapy-resistant periapical periodontitis.Multiplication of the anaerobic bacteria consisting mainly of Peptostreptococcus and Actinomyces causes sever spontaneous pain, markable swelling and pus flow and abscess formation.On the other hand, infection by Candida produces sever percussion pain and pulpation pain.

采用椅旁厌氧培养系统对32例根据临床进展诊断为难治性根尖周炎病例的根管内细菌进行了研究。所有难治性根尖周炎病例均为培养阳性。这说明难治性根尖周炎是一种感染性疾病。厌氧菌中主要分离到消化链球菌和放线菌，兼性中分离出肠球菌、葡萄球菌和肠杆菌，真菌中分离到念珠菌。这些微生物的感染可能在难治性根尖周炎的形成中起重要作用。主要由消化链球菌和放线菌组成的厌氧菌的繁殖会引起严重的自发性疼痛、明显的肿胀、流脓和脓肿形成。念珠菌引起的剧烈叩击痛和牙髓痛。

项目成果

Toda T, Yoshida M, Ikenaga H: "Bacteriorogical Studies of Pulp Tissues and Root Canals after Pulpectomy" Dentistory in Japan. 33. 50-54 (1997)

Toda T、Yoshida M、Ikenaga H：“牙髓切除术后牙髓组织和根管的细菌学研究”日本牙科。

吉田匡宏: "難治症例を治す"歯科医学. 64. 66-71 (2001)

吉田正宏：《治疗疑难病例》牙科。 64. 66-71 (2001)

吉田匡宏: "難治性根尖性歯周炎治療における「チェアーサイド嫌気培養システム」の応用-好気性グラム陰性桿菌が残留した症例-"日本歯科保存学会. 43. 383-389 (2000)

Masahiro Yoshida：“‘椅旁厌氧培养系统’在难治性根尖周炎治疗中的应用——残留需氧革兰氏阴性杆菌的病例——”日本保守牙科学会43. 383-389 (2000)。

Masahiro Yoshida: "Treatment of Incurable Endodontic Cases"J.Osaka Odontol Soc. 64. 66-71 (2001)

吉田正博：“无法治愈的牙髓病病例的治疗”J.Osaka Odontol Soc。

吉田匡宏,福島久典,池永英彰,他: "難治性根尖性歯周炎症例から分離したCandida albicansの抗生剤と根管内消毒薬に対する感受性" 日本歯科保存学雑誌. 41(1). 307-312 (1998)

Masahiro Yoshida、Hisanori Fukushima、Hideaki Ikenaga 等人：“从难治性根尖周炎病例中分离出的白色念珠菌对抗生素和根管消毒剂的敏感性”，日本保守牙科杂志 41(1) (1998)。