Effects of inhalation anesthetics on parasympathetic reflex vasodilatation

吸入麻醉药对副交感神经反射性血管舒张的影响

• 批准号: 09671886
• 负责人: IZUMI Hiroshi
• 金额: $ 1.98万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671886/
• 关键词: Inhalation; GABA; Parasympathetic; Vasodilatation; Autonomic; 自律神経; Inhalation; GABA; Parasympathetic; Vasodilatation; Autonomic; 自律神経

The present experiments were designed to examine the effects of inhalation anesthetics (isoflurane, halothane, and sevoflurane) on the parasympathetic reflex vasodilation in the lower lip and palate elicited by electrical stimulation of the central cut end of the lingual nerve in vago-sympathectomized cats. Isoflurane (1.5%), halothane (1.0 %), sevoflurane (2.5%), each at a concentration of 1.0 MAC (minimum alveolar concentra-tion), markedly suppressed the evoked blood flow increases in the lower lip, whereas nitrous oxide (70 % in 30% oxygen) and morphine (2 mg/kg, iv) did not. Prior administra-tion of picrotoxin, a GABA antagonist, (2 mg/kg, iv) reversed the inhibitory effect of isoflurane on the parasympathetic reflex response. Decerebration had no significant effect on the isoflurane-induced inhibition. These findings suggest that there is a GABA-mediated suppressive mechanism acting on this parasympathetic reflex response ; the sites at which inhalation anesthetics exert such an inhibitory action could be in the mid-brain, pons, or medulla, but not in the hypothalamus or higher structures.

目前的实验旨在检查吸入麻醉药（异氟烷，硫硫代和七氟醚）对下唇的副交感神经反射性血管舒张的影响，并通过流浪性 - 同情 - 相关性猫中舌神经的中心切割端的电刺激引起的唇酸盐，并引起上pa的影响。异氟烷（1.5％），荧光素（1.0％），七氟烷（2.5％），每种浓度为1.0 MAC（最小肺泡浓度），显着抑制了下唇的唤起的血液流量增加，而一二氮（70％的氧气中）和Morphine和Morphine（70％）（70％）（70％）（70％）（70％）（2 MG/KG）。 GABA拮抗剂（2 mg/kg，iv）Picrotoxin的先前施用逆转了异氟烷对副交感反射反应的抑制作用。解剖学对异氟烷诱导的抑制没有显着影响。这些发现表明，有一种GABA介导的抑制机制，作用于这种副交感神经反应反应。吸入麻醉剂的部位发挥这种抑制作用可能在中脑，脑海或髓质中，而不是在下丘脑或更高的结构中。