Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends
膳食物质免疫调节能力的研究及其对我们自身有益目的的应用
基本信息
- 批准号:13GS0015
- 负责人:
- 金额:$ 253.01万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Creative Scientific Research
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We started the above research project in 2001, and since 2001, distinctive features of functional crosstalk between intestinal flora, intestinal epithelial cells (IEC) and local as well as entire immune responses have been accumulated. Now, it is evident that intestinal flora and dietary substances that determine the composition of intestinal flora are important to the establishment of distinctive feature of intestinal immune response. Furthermore, it is speculated that the alteration of intestinal flora by modern dietary substances are involved in the pathogenesis of ulcerative colitis and Crohn's disease.With regard to the summary of the research project, it should be pointed out that we clarified several distinctive aspects of intestinal immune response. First, acute graft-versus-host disease (aGVHD) is initiated by immunologically competent cytotoxic T cells (CTL) that express anti-host specificities. We have corroborated for the first time that gut Peyer's patches (PP) are required to activate anti-host CTL response in a well characterized murine aGVHD model. Second, we have verified that all lymph nodes including mesenteric lymph nodes, PP and isolated lymphoid follicles are not an absolute requirement for the histogenesis of recently discovered gut cryptopatches (CP) and development of γδ-IEL in the athymic nu/nu mice. These results indicate that gut CP might be the anatomical sites to generate progenitor γδ-IEL under this extreme lymphoid depletion. Third, it has been demonstrated that interleukin 15-dependent crosstalk between conventional and plasmacytoid dendrite cells is essential for CpG-induced immune activation. Taking all of these new findings together, we have accumulated new important evidence that is essential for the investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends.
我们从2001年开始了上述研究项目,自2001年以来,肠道菌群、肠上皮细胞(IEC)和局部以及整体免疫反应之间的功能串扰的独特特征已经积累起来,现在很明显,肠道菌群和饮食之间存在相互作用。决定肠道菌群组成的物质对于建立肠道免疫反应的独特特征非常重要。此外,据推测,现代饮食物质对肠道菌群的改变与溃疡性结肠炎和溃疡性结肠炎的发病机制有关。克罗恩病。关于研究项目的总结,应该指出的是,我们阐明了肠道免疫反应的几个独特方面,首先,急性移植物抗宿主病(aGVHD)是由具有免疫能力的细胞毒性T细胞引发的。我们首次证实,在特征明确的小鼠 aGVHD 模型中,需要肠道派尔氏斑 (PP) 来激活抗宿主 CTL 反应。已经证实,所有淋巴结,包括肠系膜淋巴结、PP 和分离的淋巴滤泡,并不是最近发现的肠道隐斑 (CP) 的组织发生和无胸腺 nu/nu 小鼠中 γδ-IEL 发育的绝对必要条件。肠道 CP 可能是在这种极端淋巴耗竭下产生祖细胞 γδ-IEL 的解剖部位。第三,已证明传统和白细胞介素 15 之间的串扰。浆细胞样树突细胞对于 CpG 诱导的免疫激活至关重要,将所有这些新发现结合在一起,我们积累了新的证据,这对于研究膳食物质的免疫调节能力及其对我们自身有益的应用至关重要。
项目成果
期刊论文数量(82)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
- DOI:10.1038/ni1348
- 发表时间:2006-07-01
- 期刊:
- 影响因子:30.5
- 作者:Kuwajima, Seiichi;Sato, Taku;Ohteki, Toshiaki
- 通讯作者:Ohteki, Toshiaki
Yamazaki, M., et al.: "Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis."The Journal of Immunology. 171. 1556-1563 (2003)
Yamazaki, M. 等人:“表达高水平 IL-7 受体的粘膜 T 细胞是治疗慢性结肠炎的潜在靶点。”《免疫学杂志》。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ohteki, T., et al.: "Critical role of IL-15-IL-15R for antigen-presenting cell functions of in the innate immune response"Nature Immunology. 2. 1138-1143 (2001)
Ohteki, T. 等人:“IL-15-IL-15R 对先天免疫反应中抗原呈递细胞功能的关键作用”《自然免疫学》。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
DNA Microarray Cluster Analysis Reveals Tissue Similarity and Potential Neuron-Specific Cenes Expressed in Cranial Sensory Canglia.
DNA 微阵列聚类分析揭示了组织相似性和颅内感觉仓鼠表达的潜在神经元特异性场景。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Matsumoto;I.;Emori;Y.;Nakamura;S.;Shimizu;K.;Arai;S. Abe;K.
- 通讯作者:K.
Ohteki, T.: "Critical role for IL-15 in innate immunity"Current Molecular Medicine. 2. 371-380 (2002)
Ohteki, T.:“IL-15 在先天免疫中的关键作用”当前分子医学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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ISHIKAWA Hiromichi其他文献
ISHIKAWA Hiromichi的其他文献
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{{ truncateString('ISHIKAWA Hiromichi', 18)}}的其他基金
Distinctive immune surveillance of intestinal mucosal tissues
肠粘膜组织的独特免疫监视
- 批准号:
16043247 - 财政年份:2004
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Development and function of γδ T cells
γδ T 细胞的发育和功能
- 批准号:
12670306 - 财政年份:2000
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
6 Development and function of γδT cells
6 γδT细胞的发育和功能
- 批准号:
10670309 - 财政年份:1998
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on physiological functions of T cell bearing γδ TCR
携带γδ TCR的T细胞生理功能研究
- 批准号:
08044319 - 财政年份:1996
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for international Scientific Research
Mechanisms of human sperm acrosome reaction
人类精子顶体反应机制
- 批准号:
07457378 - 财政年份:1995
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development and physiological role of gammadeltaT cells.
gammadeltaT 细胞的发育和生理作用。
- 批准号:
07044293 - 财政年份:1995
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for international Scientific Research
cryopreservation of human semen with male infertility
男性不育症人类精液的冷冻保存
- 批准号:
05671338 - 财政年份:1993
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Development and physiological role of gammadelta T cells.
γδ T 细胞的发育和生理作用。
- 批准号:
05044185 - 财政年份:1993
- 资助金额:
$ 253.01万 - 项目类别:
Grant-in-Aid for international Scientific Research
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