Coordination Funds

协调基金

• 批准号: 507075933
• 负责人: Professorin Dr. Agnes Flöel
• 金额: --
• 依托单位: Klinik und Poliklinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/507075933?language=en
• 关键词: Coordination; Funds

Non-invasive transcranial direct current stimulation (tDCS) has recently received substantial attention in experimental and clinical science, because it allows modulation of human brain function without significant adverse effects. However, despite widespread and often successful use of this technique, little systematic research into the mechanisms underlying frequently observed highly variable effects of tDCS has been accomplished. Currently, this results in suboptimal use of this promising technique in experimental and clinical contexts. The overarching objective of the proposed Research Unit (RU) is to address this knowledge gap by investigating tDCS effects for the first time in a systematic, comprehensive and coordinated way, by a multidisciplinary and complementary team of leading experts in their respective fields. Due to its exceptional relevance for experimental and translational research, human learning and memory function will serve as a model to study tDCS effects across four functional domains (i.e., visual-spatial, language, motor, and executive) and across the human lifespan. Eight empirical projects (Projects P1-8; two per domain) will use comparable methods, individualized and targeted stimulation, highly controlled experimental settings, and tDCS application during concurrent functional imaging to investigate behavioral and neural mechanisms and predictors of stimulation response. Two overarching projects (P9, P10) will (1) relate the outcomes of biophysical models of individualized current flow to behavioral and neural modulations using the large, coordinated dataset acquired in the empirical projects and (2) cross-validate and improve current flow simulations by using in-vivo magnetic current density imaging measurements. A final project (P11) will be concerned with macro-level analyses using advanced data mining methods (i.e., machine learning, artificial intelligence) to reveal shared and differential effects and predictors of tDCS effects on behavior and brain function across projects, functional domains, and the human lifespan. Collaborative activities within the RU will be facilitated by the coordination project that is also responsible for cross-project data management and sharing by adhering to highest standards in the field.In sum, the proposed RU will generate fundamental insights into the neural mechanisms and predictors of tDCS response across the human lifespan, thereby informing theoretical concepts of the mechanisms-of-action by which current flow alters neural activity. From a methodological point of view, we will be able to optimize and validate biophysical models of current flow using an unprecedented dataset. Together, this will substantially advance future experimental and translational applications of tDCS in health and disease.

非侵入性经颅直流电流刺激（TDC）最近在实验和临床科学中受到了极大的关注，因为它可以调节人脑功能而没有明显的不良影响。但是，尽管广泛使用了这种技术，但对经常观察到的TDC效应的机制的系统研究很少。当前，这导致在实验和临床环境中这种有希望的技术次优。拟议的研究部门（RU）的总体目标是通过由多学科和互补的领先专家组成的领域领域的多学科和互补团队以系统的，全面和协调的方式来解决TDCS效应，以解决这一知识差距。由于其与实验和翻译研究的非凡相关性，人类的学习和记忆功能将成为研究跨四个功能领域（即视觉空间，语言，运动和执行）以及整个人类寿命的TDCS效应的模型。八个经验项目（项目P1-8；每个域两个）将使用可比的方法，个性化和靶向刺激，高度控制的实验设置以及在同时功能成像期间应用TDCS应用，以研究刺激反应的行为和神经机制以及刺激反应的预测指标。两个总体项目（P9，P10）（1）将使用在经验项目中获得的大型，协调的数据集将个性化电流流的生物物理模型与行为和神经调节次数联系起来，以及（2）通过使用Vivo In-Vivo磁性电流密度成像测量结果。最终项目（P11）将使用高级数据挖掘方法（即机器学习，人工智能）进行宏观分析，以揭示TDCS的共享和差异效应以及对跨项目，功能领域和人类寿命的行为和大脑功能的影响。协调项目将促进RU内部的协作活动，该项目还负责跨项目管理并通过遵守该领域的最高标准来共享。总而言之，拟议的RU将在人类终身概念中逐渐了解TDCS响应的神经机制和对TDCS响应的神经机制和预测因子，从而通过该机制进行了依据。从方法论的角度来看，我们将能够使用前所未有的数据集优化和验证电流流的生物物理模型。总之，这将大大推动TDC在健康和疾病中的未来实验和翻译应用。