Mechanisms of action of oscillatory transcranial direct current stimulation during sleep on electrophysiological correlates and memory consolidation – assessed via presurgically implanted electrodes in patients with epilepsy

睡眠期间振荡经颅直流电刺激对电生理相关性和记忆巩固的作用机制 â 通过术前植入的电极对癫痫患者进行评估

• 批准号: 413459402
• 负责人: Professorin Dr. Agnes Flöel
• 金额: --
• 依托单位: Klinik und Poliklinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/413459402?language=en
• 关键词: Mechanisms; action; oscillatory; transcranial; direct

The main aim of this study is to elucidate the mechanisms underlying sleep-dependent memory consolidation. We will evaluate patients implanted presurgically with intracranial electrodes for treatment of pharmacorefractory epilepsy. In a balanced cross-over design, we will apply either slow oscillatory transcranial anodal direct current stimulation (sotDCS) or sham stimulation during a 90 min nap. During sleep, we will record slow cortical oscillations (SO), spindles, and ripples, using surface EEG and invasive EEG. Moreover, several memory tasks will be learned before sleep, and sleep-dependent memory consolidation will be evaluated after sleep as a function of the stimulation condition. The following questions will be addressed: a) Is the hierarchical coupling between SO-to- spindles, and spindles-to-ripples in the hippocampus, associated with the ability to consolidate novel memories? b) What is the impact of so-tDCS on hippocampal-thalamo-cortical networks, and particularly hippocampal ripple-activity? c) Is the modulation of coupling of SO-to-spindles, and spindles-to-ripples, associated with the ability to consolidate novel memories? d) Does the so-tDCS-Effects on SO, spindles, and ripples persist after end of stimulation, and do the after-effects depend on entrainment? Combination of a perturbation approach with so-tDCS, and intracranial recordings in epilepsy patients offers the unique possibility to assess subcortical oscillations including hippocampal ripple-activity with regard to their causal relevance for successful memory consolidation. In addition to furthering basic neuroscientific knowledge, the study will allow us to evaluate and to improve the therapeutic potential of sot-DCS with regard to improving sleep-dependent memory consolidation in aging and in incipient neurodegenerative disease. So-tDCS, as a non-invasive and low-risk treatment approach that targets sleep and its neurophysiological correlates, may convey symptomatic (memory consolidation) and possibly even causal (amyloid-clearance) benefit to patients, an issue of great clinical relevance. However, before testing this approach in larger clinical studies in relevant patient cohorts, it is paramount to optimize the intervention, on the basis of a more thorough understanding of the underlying mechanisms that will result from the present study.

这项研究的主要目的是阐明睡眠依赖性记忆巩固的机制。我们将用颅内电极预先植入的患者治疗药物治疗癫痫。在平衡的跨界设计中，我们将在90分钟的NAP中应用缓慢的振荡经颅阳极直流电流刺激（SOTDC）或假刺激。在睡眠期间，我们将使用表面脑电图和侵入性脑电图记录缓慢的皮质振荡（SO），纺锤体和波纹。此外，睡眠前将学习几个记忆任务，并且在睡眠后将评估睡眠依赖性记忆合并作为刺激条件的函数。将解决以下问题：a）与巩固新型记忆的能力有关的海马之间的层次结构和海马中的纺锤之间的层次耦合？ b）SO-TDC对海马 - 丘脑皮层网络有什么影响，尤其是海马纹波 - 活动性？ c）与巩固新记忆的能力相关的So-to-tospindles和纺锤之间的耦合的调节是否？ d）SO-TDCS效应是否在刺激结束后，纺锤体和涟漪持续存在，后效应是否取决于夹带？癫痫患者的扰动方法与SO-TDC的组合以及颅内记录的结合提供了评估皮层振荡的独特可能性，包括海马纹波活性在其成功记忆巩固方面的因果关系。除了进一步发展基本的神经科学知识外，该研究还将使我们能够评估并提高SOT-DC在改善衰老和初始神经退行性疾病中睡眠依赖性记忆巩固方面的治疗潜力。 SO-TDC作为靶向睡眠及其神经生理学相关性的一种非侵入性和低风险治疗方法，可能传达症状性（记忆巩固），甚至可能对患者的因果（淀粉样蛋白清除率）受益，这是一个很大的临床相关性。 但是，在相关患者同类群体中的较大临床研究中测试这种方法之前，根据对本研究将导致的基本机制的更彻底的理解，优化干预措施至关重要。