Dynamic behavior of plant polyphenols in biological membranes

植物多酚在生物膜中的动态行为

• 批准号: 17580115
• 负责人: NAKAYAMA Tsutomu
• 金额: $ 2.24万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17580115/
• 关键词: catechin; polyphenol; phospholipid; lipid membrane; liposome; NMR; EGCg; bicelle; リボソーム; 固体MR; EGCG; カテキン類; ECg; 固体NMR; 脂質二十層; バイセル膜

Interaction between tea catechins, such as epicatechin gallate (ECg) and epigallocatechin gallate (EGCg), and isotropic bicelle model lipid membranes was investigated by solution NMR techniques. ^1HNMR measurements provided signals from the B-ring and the galloyl moiety in ECg and EGCg that were obviously shifted, and whose proton T_1 relaxation times were shortened upon interaction of the catechins with the bicelles. These results indicate that the B-ring and the galloyl moiety play an important role in this interaction. Nuclear Overhauser effect spectrometry experiments demonstrated that the B-ring and the galloyl moiety are located near the γ-H in the phospholipid trimethylammonium group. On the basis of these findings, we propose that ECg and EGCg interact with the surface of lipid membranes via the choline moiety.

通过溶液NMR技术研究了茶儿茶素（例如Epicatechin Gallate（ECG）和Epigallocatechin Gallate（EGCG））的相互作用。 Galloyl部分在TOLE相互作用中起重要作用。

项目成果

Advances in Planar Lipid Bilayers and liposomes, Vol. 4

平面脂质双层和脂质体的进展，卷。

• 发表时间: 2006
• 作者: T.Nakayama;K.Kajiya;S.Kumazawa
• 通讯作者: S.Kumazawa

Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR spectroscopy

• DOI: 10.1021/jf0712402
• 发表时间: 2007-11-28
• 期刊: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
• 影响因子: 6.1
• 作者: Uekusa, Yoshinori;Kamihira, Miya;Nakayama, Tsutomu
• 通讯作者: Nakayama, Tsutomu

Interaction of Plant Polyphenols with Liposomes

• DOI: 10.1016/s1554-4516(06)04004-x
• 发表时间: 2006-01-01
• 期刊: ADVANCES IN PLANAR LIPID BILAYERS AND LIPOSOMES, VOL 4
• 作者: Nakayama, Tsutomu;Kajiya, Katsuko;Kumazawa, Shigenori
• 通讯作者: Kumazawa, Shigenori

Advances in Planar Lipid Bilayers and Liposomes, Vol.4

平面脂质双层和脂质体的进展，第 4 卷

• 发表时间: 2006
• 作者: T.Nakayama;K.Kajiya;S.Kumazawa
• 通讯作者: S.Kumazawa