The relationship between occiusal disharmony and hypothalamus in the rat

大鼠咬合不协调与下丘脑的关系

• 批准号: 14571958
• 负责人: YOSHIHARA Toshihiro
• 金额: $ 1.86万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571958/
• 关键词: occlusal disharmony; locomotor activity; restrsleeping; hypothalamus; corticosterone; stress

Few neuroendocrinological studies have examined the relationship between occiusal disharmony and stress. To determine the effect of occiusal disharmony on the central nervous system, we measured plasma corticosterone and extracellular noradrenaline in the vicinity of the hypothalamic paraventricular nucleus in rats with and without incisal caps.After setting the caps, plasma corticosterone and extracellular noradrenaline levels gradually increased, reaching a peak at 8.5 and at 6.5 hours respectively, after which they decreased.Furthermore, plasma corticosterone and extracellular noradrenaline levels increased in a circadian fashion around the onset of the dark phase in rats without caps, but not in rats with caps.These results suggest that occiusal disharmony causes chronic stress in the rat.

很少有神经内分泌学研究探讨了咬合不和谐与压力之间的关系。为了确定咬合不和谐对中枢神经系统的影响，我们测量了有和没有切帽的大鼠下丘脑室旁核附近的血浆皮质酮和细胞外去甲肾上腺素水平。设置帽后，血浆皮质酮和细胞外去甲肾上腺素水平逐渐升高，分别在8.5小时和6.5小时达到峰值，之后下降。此外，血浆皮质酮和细胞外皮质酮在没有戴帽子的大鼠中，去甲肾上腺素水平在黑暗阶段开始时以昼夜节律方式增加，但在戴帽子的大鼠中则不然。这些结果表明咬合不和谐会导致大鼠慢性应激。

项目成果

Toshihiro Yoshihara, Koki Shigeta, Hiroko Hasegawa, Norihito Ishihtani, Yasuhiro Masumoto: "Neuroendocrine responses to stress among patients with myofascial pain dysfunction syndrome."Journal of Orofacial Pain. (印刷中). (2004)

Toshihiro Yoshihara、Koki Shigeta、Hiroko Hasekawa、Norihito Ishihtani、Yasuhiro Masumoto：“肌筋膜疼痛功能障碍综合征患者对压力的神经内分泌反应”。口面部疼痛杂志（2004 年）。

Toshihiro Yoshihara, Koki Shigeta, Hiroko Hasegawa, Norihito Ishitani, Yasuhiro Masumoto, Youichi Yamasaki: "Neuroendocrine response to stress among patients with myofascial pain dysfunction syndrome."Journal of Orofacial Pain. (in press). (2004)

Toshihiro Yoshihara、Koki Shigeta、Hiroko Hasekawa、Norihito Ishitani、Yasuhiro Masumoto、Youichi Yamasaki：“肌筋膜疼痛功能障碍综合征患者对压力的神经内分泌反应。”口面部疼痛杂志。

Toshihiro Yoshihara, Yuko Matsumoto, Junichi Suzuki, Tadashi Ogura: "Effect of serial extraction alone on crowding : relationship between closure of residual extraction space and changes in dentition."Journal of Clinical Pediatric Dentistry. 26. 10-11 (20

Toshihiro Yoshihara、Yuko Matsumoto、Junichi Suzuki、Tadashi Ogura：“单独连续拔牙对拥挤的影响：残余拔牙间隙的闭合与牙列变化之间的关系。”临床儿科牙科杂志。

Toshihiro Yoshihara: "Neuroendocrine responses to stress among patients with myofascial pain dysfunction syndrome."Journal of Orofacial Pain. (in press).

Toshihiro Yoshihara：“肌筋膜疼痛功能障碍综合征患者对压力的神经内分泌反应。”口面部疼痛杂志。