A neuroendocrinological study on the mechanism of activation of neurotransmitter by mastication

咀嚼激活神经递质机制的神经内分泌学研究

• 批准号: 10671920
• 负责人: YOSHIHARA Toshihiro
• 金额: $ 1.79万
• 依托单位: Kagoshima University (1999)Hokkaido University (1998)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671920/
• 关键词: mastication; learning; memory; neuropeptide Y; rat; 迷路学習; mastication; learning; memory; neuropeptide Y; rat; 迷路学習

Effects of mastication were examined on the learning and memory in rats. The following result was obtained.(1) In Hebb and Williams' maze test, twenty-four Wistar rats were divided into four groups: rats which were fed normal solid meal (Solid Rats), liquid meal (Liquid Rats), intravenous hyperalimentation through jugular vein (IH Rats) or liquid meal infusion through cardiac part of stomach (LMI Rats). The total error score of the Solid Rats were significantly less than that of the Liquid Rats. The total error score of the Liquid Rats were significantly less than those of the IH Rats and the LMI Rats. There was no significant difference of the total error scores between IH Rat and LMI Rat.(2) Neuropeptide Y (NPY) concentrations in hypothalamus (paraventricular nucleus and arcuate nucleus) of the above-mentioned rats were measured. NPY concentration in Solid Rat was significantly higher than that in Liquid Rat. And NPY concentration in Liquid Rat was significantly higher than that in IH Rat and LMI Rat. There was no significant difference of NPY concentration between IH Rat and LMI Rat.These results suggest that food intake through mouth, particularly with mastication, is important for development of ability of learning in rats and that NPY is involved in this mechanism of development.

检查了咀嚼的影响对大鼠的学习和记忆。 （1）在Hebb和Williams的迷宫测试中，将二十四只Wistar大鼠分为四组：喂食正常的固体餐（固体大鼠），液体粉（液体大鼠），静脉内过度情感，通过颈静脉（IH大鼠）或液体饮食液体饮食（IH大鼠）或通过心脏饮食液通过胃部（Lmi to lmi ta）。固体大鼠的总误差评分明显小于液体大鼠的总误差。液体大鼠的总误差得分明显小于IH大鼠和LMI大鼠的总误差。 IH大鼠和LMI大鼠之间的总误差评分没有显着差异。（2）测量上述大鼠的下丘脑（脑室核和弧形核）的神经肽Y（NPY）浓度。固体大鼠的NPY浓度显着高于液体大鼠。液体大鼠的NPY浓度显着高于IH大鼠和LMI大鼠的NPY浓度。 IH大鼠和LMI大鼠之间的NPY浓度没有显着差异。这些结果表明，通过口腔的食物摄入量，尤其是在咀嚼方面，对于大鼠学习能力的发展至关重要，并且NPY参与了这种发育机制。