STUDY ON THE BENEFICIAL EFFECT OF ALLERGY LABELLING SYSTEM OF PROESSED FOODS ON THE QUALITY OF LIFE OF CHILDREN WITH FOOD ALLERGY AND ITS CLINICAL EVALUATION

加工食品过敏标签制度对食物过敏儿童生活质量的有益影响及其临床评价

基本信息

批准号：
15500557
负责人：
ITO Setsuko
金额：
$ 2.37万
依托单位：
DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

The beneficial effect of allergy labeling system of specified ingredients in the processed foods on the quality of life (QOL) of children with food allergy was studied using questionnaire for parents, pediatricians, nursing staff and dietitian. QOL of infants with food allergy was considered to have improved thanks to allergy labeling system only by 57.4% of their parents, 59.1% of dietitians, 45.7% of pediatricians, 38.5% of nursing staffs. More than half of them had difficulty in understanding the alternative declaration of specified ingredients.20.0% of pediatricians had experienced patients who demonstrated hypersensitivity reaction after intake of processed food with no labeling about allergen concerned with the reaction. There were foods without labeling in which more than 10μg/g of allergen were contained and foods in which the concentration of allergen was less than 10μg/g, but the amount of allergen exceeded 200μg as a meal: enough amount to cause allergic reaction in highly sensitized infants.We could establish ELISA system to assay the amount of egg antigen in foods with sensitivity and specificity compatible with commercially available specified measuring kit for ovalbumin. This system was not suitable for the detection of egg protein as an ingredient but was suitable to evaluate reduction of allergenicity compatible with clinical observation. Studies on the basophil histamine release test revealed that the amount of several ng of allergen was enough to release histamine from basophils separated from peripheral blood, indicating the possibility of necessity of labeling of smaller amount of specified ingredients than the existing system.These results were included n the dietary counseling guideline for clinical use.

通过对食物过敏婴儿的父母、儿科医生、护理人员和营养师进行问卷调查，研究了加工食品中特定成分的过敏标签制度对食物过敏儿童的生活质量（QOL）的有益影响。由于过敏标签系统，只有 57.4% 的父母、59.1% 的营养师、45.7% 的儿科医生、38.5% 的护理人员有改善。超过半数的人难以理解指定成分的替代声明。20.0%的儿科医生曾遇到过因摄入未标注与反应有关的过敏原的加工食品而出现过敏反应的患者。过敏原含量低于10μg/g，以及过敏原浓度低于10μg/g，但膳食中过敏原含量超过200μg的食物：足够的量我们可以建立ELISA系统来测定食品中的卵抗原含量，其灵敏度和特异性与市售的卵清蛋白专用测定试剂盒相匹配，但该系统不适合作为卵清蛋白的检测。成分，但适合评估与临床观察相一致的过敏性降低。对嗜碱性粒细胞组胺释放试验的研究表明，几纳克的过敏原足以从外周血分离的嗜碱性粒细胞中释放组胺。血液，表明可能需要比现有系统标记更少量的特定成分。这些结果被纳入临床使用的膳食咨询指南中。