Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials

生物相容性聚合物合金作为生物材料的结构控制和功能

基本信息

批准号：
13480288
负责人：
ISHIHARA Kazuhiko
金额：
$ 9.41万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

In this research, polymer alloys composed of conventional polymer materials, such as, polyurethane and polysulfone, polyolefine and newly designed phospholipid polymers were researched as follows :To improve the biocompatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer was blended in the SPUs, such as Pellethane【○!R】 and TM-3【○!R】, by a solvent evaporation method from a homogeneous solution containing both SPU and MPC copolymer. X-ray electron spectra(XPS) indicated that the MPC moieties were located at the surface of the SPU membrane blended with the MPC copolymer even when the composition of the MPC copolymer was only 7.5 w/w % against the matrix SPU. The mechanical property of the SPU membranes, as determined by tensile stress-strain measurements, changed very little by addition of the MPC copolymer. Biocompatibility of the MPC copolymer blended membrane was evaluated by plasma protein adsorption and blood cell adhesion on the surfa … More ce. The amount of fibrinogen adsorbed on the SPU membrane significantly decreased by addition of the MPC copolymers. Moreover, addition of MPC copolymer in the SPU membrane suppressed platelet adhesion and activation. It is concluded that the blending of the MPC copolymer in the SPU membrane is an effective method to improve biocompatibility of the SPU membrane.Nonfouling polysulfone hollow fiber membranes from protein adsorption and deposition were newly developed by addition of MPC polymer. To improve hydrophilicity, permeability, and nonfouling characteristics of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer, which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The composition of the MPC polymer blended in the PSf was in the range between 7.0 and 15-wt%. From the PSf/MPC polymer solution, flat membranes and hollow fiber could be prepared. These membranes took an asymmetric structure and its mechanical strength was good. The surface characterization of the PSf/MPC polymer hollow fiber membrane by XPS revealed that the MPC units were concentrated at the surface. The permeability for solutes through the PSf/MPC polymer membrane was higher and the amount of protein adsorbed on the PSf/MPC polymer membrane was lower than those of the PSf membrane. Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer membrane Less

在这项研究中，研究了由传统聚合物材料组成的聚合物合金，例如聚氨酯和聚硫酮，聚甲基，聚甲基和新设计的磷脂聚合物，如下：改善分段的聚氨酯（SPU）的生物相容性，2-甲基乙烯基丙烯酰丙烯酰氧基甲基甲基甲基甲基氯氯氯壳酶（MPCCCCC），以及菌群（MPC）菌群（MPCCC）。素[○！r]和TM-3 [○！r]，通过包含SPU和MPC共聚物的均匀溶液的溶剂经济方法。 X射线电子光谱（XPS）表明，即使MPC共聚物的组成仅为MATRIX SPU，MPC部分位于SPU膜表面与MPC共聚物的表面。由拉伸应力应变测量确定的SPU膜的机械性能通过添加MPC共聚物而几乎没有变化。 MPC共聚物混合膜的生物相容性通过血浆蛋白的吸附和在冲浪上的血细胞粘合剂进行评估……更多。通过添加MPC共聚物，在SPU膜上吸附的纤维蛋白原量显着降低。此外，在SPU膜中添加MPC共聚物抑制了血小板粘合剂和激活。结论是，SPU膜中MPC共聚物的混合是提高SPU膜的生物相容性的有效方法。通过添加MPC聚合物，新开发了蛋白质成瘾中的多硫硫0硫酮中空纤维膜。为了改善血液赖斯利亚PSF空心纤维的亲水性，渗透性和非结合特性，我们合成了MPC聚合物，可以将其与PSF混合以制备聚合物合金（PSF/MPC聚合物）。在PSF中混合的MPC聚合物的组成在7.0 wt％至15 wt％之间。从PSF/MPC聚合物溶液中，可以制备平坦的机理和空心纤维。这些机制采用了不对称结构，其机械强度很好。 XPS的PSF/MPC聚合物空心纤维膜的表面表征表明，MPC单元集中在表面。通过PSF/MPC聚合物膜的太阳能渗透性更高，并且在PSF/MPC聚合物膜上吸附的蛋白质量低于PSF膜的蛋白质。此外，血小板粘附也有效地抑制了PSF/MPC聚合物膜较少